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Tbio
AACS
Acetoacetyl-CoA synthetase

Protein Summary
Description
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316519
  • ENSP00000324842
  • ENSG00000081760

Symbol
  • ACSF1
  • ACSF1
  • SUR-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
1
molecular function
0.9
biological process
0.82
histone modification site profile
0.76
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
p_int:  0.970275002
p_ni:  6.1e-8
p_wrong:  0.029724937
Data Source:  BioPlex
ACAT1
Tchem
Family:  Enzyme
Novelty:  0.00908928
Score:  0.955
Data Source:  STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
Score:  0.95
Data Source:  STRINGDB
HMGCS2
Tbio
Family:  Enzyme
Novelty:  0.0103808
Score:  0.947
Data Source:  STRINGDB
BDH1
Tbio
Family:  Enzyme
Novelty:  0.01229995
Score:  0.937
Data Source:  STRINGDB
ACAT2
Tchem
Family:  Enzyme
Novelty:  0.01464168
Score:  0.935
Data Source:  STRINGDB
HMGCL
Tbio
Family:  Enzyme
Novelty:  0.02741994
Score:  0.932
Data Source:  STRINGDB
HADH
Tbio
Family:  Enzyme
Novelty:  0.00368073
Score:  0.931
Data Source:  STRINGDB
BDH2
Tbio
Family:  Enzyme
Novelty:  0.04118875
Score:  0.922
Data Source:  STRINGDB
HMGCLL1
Tbio
Family:  Enzyme
Novelty:  0.13131046
Score:  0.915
Data Source:  STRINGDB
Pathways (8)
Ketone body metabolism (R-HSA-74182)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Ketone Bodies
Name
Explore in Pharos
Explore in Source
Ketone body metabolism
Metabolism
Metabolism of lipids
Synthesis of Ketone Bodies
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acetoacetyl-CoA synthetase
VGNC:51241
452361
Macaque
acetoacetyl-CoA synthetase
707015
Mouse
MGI:1926144
78894
Rat
RGD:708522
65984
Dog
acetoacetyl-CoA synthetase
VGNC:37403
486240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acetoacetyl-CoA synthetase
Macaque
acetoacetyl-CoA synthetase
Mouse
Rat
Dog
acetoacetyl-CoA synthetase
Publication Statistics
PubMed Score 72.78
PubMed score by year
PubTator Score 16.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title