Tbio SHLD2 Shieldin complex subunit 2

Protein Summary

Description

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).

Uniprot Accession IDs

• Q86V20
• O95885
• Q9H991

Gene Name

• SHLD2

Ensembl ID

• ENST00000298784
• ENSP00000298784
• ENSG00000122376
• ENST00000298786
• ENSP00000298786

Symbol

• FAM35A
• RINN2
• RINN2
• FAM35A
• FAM35A1
• bA163M19.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.77
kinase perturbation	0.71
tissue sample	0.71
cellular component	0.57
cell line	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0