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Tbio
CASZ1
Zinc finger protein castor homolog 1

Protein Summary
Description
Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344008
  • ENSP00000339445
  • ENSG00000130940
  • ENST00000377022
  • ENSP00000366221

Symbol
  • CST
  • SRG
  • ZNF693
  • CST
  • SRG
  • CAS11
  • ZNF693
  • dJ734G22.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
microRNA
0.71
transcription factor
0.7
tissue sample
0.67
phenotype
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.28   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.28   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (43)
1 – 10 of 43
ZFP1
Tbio
Family:  TF
Novelty:  0.02526416
Score:  0.907
Data Source:  STRINGDB
EGFL7
Tbio
Novelty:  0.01148912
Score:  0.738
Data Source:  STRINGDB
LRG1
Tbio
Novelty:  0.00445522
Score:  0.681
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.647
Data Source:  STRINGDB
ARHGAP40
Tdark
Family:  Enzyme
Novelty:  4.12645161
Score:  0.647
Data Source:  STRINGDB
APOOL
Tbio
Novelty:  0.08233023
Score:  0.596
Data Source:  STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
Score:  0.586
Data Source:  STRINGDB
CAMTA1
Tbio
Family:  TF
Novelty:  0.013932
Score:  0.575
Data Source:  STRINGDB
CCAR1
Tbio
Novelty:  0.03257229
Score:  0.548
Data Source:  STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.548
Data Source:  STRINGDB
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
3
3
94.9
3
1
0
2.1
86.9
Varicose veins
1
1
1
86.6
Calcium channel blocker use measurement
1
1
1
79.9
Diuretic use measurement
1
1
1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
94.9
0
2.1
86.9
Varicose veins
1
86.6
Calcium channel blocker use measurement
1
79.9
Diuretic use measurement
1
77.7
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
castor zinc finger 1
VGNC:462
457931
Mouse
MGI:1196251
69743
Rat
RGD:1563533
313713
Horse
castor zinc finger 1
VGNC:50674
100056838
Cow
castor zinc finger 1
VGNC:50113
536765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
castor zinc finger 1
Mouse
Rat
Horse
castor zinc finger 1
Cow
castor zinc finger 1
Publication Statistics
PubMed Score 80.28
PubMed score by year
PubTator Score 24.93
PubTator score by year