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Tbio
ZBTB46
Zinc finger and BTB domain-containing protein 46

Protein Summary
Description
Function as a transcriptional repressor for PRDM1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245663
  • ENSP00000245663
  • ENSG00000130584
  • ENST00000302995
  • ENSP00000303102
  • ENST00000395104
  • ENSP00000378536

Symbol
  • BTBD4
  • ZNF340
  • BZEL
  • BTBD4
  • RINZF
  • ZNF340
  • dJ583P15.7
  • dJ583P15.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.65
biological process
0.63
microRNA
0.63
phenotype
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (63)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
4
0
1.4
96.6
8
3
0
1.4
94.9
3
2
0
1.4
92.5
C-reactive protein measurement
3
3
3
90.6
forced expiratory volume
2
2
2
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.6
0
1.4
94.9
0
1.4
92.5
C-reactive protein measurement
3
90.6
forced expiratory volume
2
88.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 46
VGNC:10063
470037
Macaque
zinc finger and BTB domain containing 46
695166
Mouse
MGI:1919397
72147
Rat
RGD:1307408
311718
Dog
zinc finger and BTB domain containing 46
VGNC:54746
485980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 46
Macaque
zinc finger and BTB domain containing 46
Mouse
Rat
Dog
zinc finger and BTB domain containing 46
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86UZ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (50)
1 – 10 of 50
ZBTB10
Tbio
Family:  TF
Novelty:  0.05707286
p_int:  0.999984419
p_ni:  0.000015579
p_wrong:  3e-9
Data Source:  BioPlex
FBXL17
Tbio
Novelty:  0.16122137
p_int:  0.999839343
p_ni:  0.00016065
p_wrong:  7e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
p_int:  0.997172053
p_ni:  0.002827947
Score:  0.271
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.989659795
p_ni:  0.010340205
Score:  0.52
Data Source:  BioPlex,STRINGDB
EHMT2
Tchem
Family:  Epigenetic
Novelty:  0.00262578
p_int:  0.984154005
p_ni:  0.015845984
p_wrong:  1.1e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.964550041
p_ni:  0.035449959
Score:  0.398
Data Source:  BioPlex,STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.961834222
p_ni:  0.038165778
Score:  0.16
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.956178854
p_ni:  0.043821146
Score:  0.156
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.952894588
p_ni:  0.047105412
Score:  0.175
Data Source:  BioPlex,STRINGDB
WIZ
Tbio
Family:  TF
Novelty:  0.04458547
p_int:  0.935885485
p_ni:  0.064114515
Score:  0.183
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  23.30

PubMed score by year
PubTator Score  7.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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