You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAM83A
Protein FAM83A

Protein Summary
Description
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276699
  • ENSP00000276699
  • ENSG00000147689
  • ENST00000518448
  • ENSP00000428876
  • ENST00000522648
  • ENSP00000427979
  • ENST00000536633
  • ENSP00000445218

Symbol
  • TSGP
  • BJ-TSA-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
cell type or tissue
0.74
microRNA
0.67
transcription factor
0.59
tissue sample
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0