Tbio FAM83A Protein FAM83A

Protein Summary

Description

Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.

Uniprot Accession IDs

• Q86UY5
• Q71HL2
• Q8N7I1
• Q96I47

Gene Name

• FAM83A

Ensembl ID

• ENST00000276699
• ENSP00000276699
• ENSG00000147689
• ENST00000518448
• ENSP00000428876
• ENST00000522648
• ENSP00000427979
• ENST00000536633
• ENSP00000445218

Symbol

• TSGP
• BJ-TSA-9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.84
cell type or tissue	0.74
microRNA	0.67
transcription factor	0.59
tissue sample	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0