Tbio FERMT3 Fermitin family homolog 3

Protein Summary

Description

Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q86UX7
• Q8IUA1
• Q8N207
• Q9BT48

Gene Name

• FERMT3

Ensembl ID

• ENST00000279227
• ENSP00000279227
• ENSG00000149781
• ENST00000345728
• ENSP00000339950

Symbol

• KIND3
• MIG2B
• URP2
• URP2
• KIND3
• MIG-2
• MIG2B
• URP2SF
• UNC112C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
protein domain	0.73
transcription factor	0.7
transcription factor perturbation	0.68
tissue sample	0.66

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (63)

Reactome (4)

KEGG (1)

WikiPathways (58)

Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Reactome	Platelet degranulation	128 targets	R-HSA-114608
Reactome	Response to elevated platelet cytosolic Ca2+	133 targets	R-HSA-76005

Name	Explore in Pharos	Explore in Source
Hemostasis	666 targets	R-HSA-109582
Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Platelet degranulation	128 targets	R-HSA-114608
Response to elevated platelet cytosolic Ca2+	133 targets	R-HSA-76005

Gene Ontology Terms (16)

Functions (1)

Components (7)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
integrin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Protein-Protein Interactions (166)

Explore Interacting Targets

1 – 10 of 166

• See Interactions on String-DB

FERMT1

Tbio

Novelty: 0.01042342

p_int: 0.999999261

p_ni: 7.09e-7

p_wrong: 2.9e-8

Score: 0.841

Data Source: BioPlex,STRINGDB

IPP

Tbio

Novelty: 0.00107504

p_int: 0.999292791

p_ni: 0.000698585

p_wrong: 0.000008623

Score: 0.275

Data Source: BioPlex,STRINGDB

FERMT2

Tbio

Novelty: 0.01142925

p_int: 0.956535122

p_ni: 0.042216949

p_wrong: 0.001247929

Score: 0.864

Data Source: BioPlex,STRINGDB

ITGB3

Tclin

Novelty: 0.00086996

Score: 0.946

Data Source: STRINGDB

FBLIM1

Tbio

Novelty: 0.04280121

Score: 0.942

Data Source: STRINGDB

FN1

Tchem

Novelty: 0.0000437

Score: 0.938

Data Source: STRINGDB

SRGN

Tbio

Novelty: 0.00370492

Score: 0.934

Data Source: STRINGDB

VWF

Tbio

Novelty: 0.00010911

Score: 0.929

Data Source: STRINGDB

MMRN1

Tbio

Novelty: 0.00940351

Score: 0.924

Data Source: STRINGDB

ACTN1

Tbio

Novelty: 0.01041776

Score: 0.922

Data Source: STRINGDB

Publication Statistics

PubMed Score  81.00

PubMed score by year

Reset Zoom

PubTator Score  74.64

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell adhesion
Cell junction
Cell projection
Complete proteome
Direct protein sequencing
Disease mutation
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

Agents acting on the renin-angiotensin system use measurement
BMI-adjusted waist-hip ratio
body mass index
cognitive function measurement
diet measurement
heel bone mineral density
high density lipoprotein cholesterol measurement
HMG CoA reductase inhibitor use measurement
platelet count
reticulocyte count

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
digestive/alimentary phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
nervous system phenotype
skeleton phenotype