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Tbio
ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

Protein Summary
Description
May act as a tumor suppressor. This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256861
  • ENSP00000256861
  • ENSG00000123243
  • ENST00000298441
  • ENSP00000298441

Symbol
  • KIAA1953
  • ITI-HC5
  • PP14776
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
transcription factor perturbation
0.74
tissue
0.71
histone modification site profile
0.61
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.45   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.45   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
NEK9
Tchem
Family:  Kinase
Novelty:  0.02386353
p_int:  0.760441637
p_ni:  0.239558363
Data Source:  BioPlex
TMCC1
Tbio
Novelty:  0.13345982
Score:  0.604
Data Source:  STRINGDB
TIMM17A
Tbio
Family:  Enzyme
Novelty:  0.02095904
Score:  0.595
Data Source:  STRINGDB
CHCHD3
Tbio
Novelty:  0.05341939
Score:  0.563
Data Source:  STRINGDB
ANKRD16
Tdark
Novelty:  0.78790347
Score:  0.562
Data Source:  STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
Score:  0.55
Data Source:  STRINGDB
CHCHD6
Tbio
Novelty:  0.12379343
Score:  0.54
Data Source:  STRINGDB
GRAMD1B
Tbio
Novelty:  0.2994102
Score:  0.54
Data Source:  STRINGDB
PNCK
Tchem
Family:  Kinase
Novelty:  0.13037374
Score:  0.537
Data Source:  STRINGDB
SFMBT1
Tbio
Family:  Epigenetic
Novelty:  0.00324281
Score:  0.532
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
1
1
1
88.3
superior temporal gyrus volume measurement
2
1
0
7.1
64.4
mean reticulocyte volume
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
1
88.3
superior temporal gyrus volume measurement
0
7.1
64.4
mean reticulocyte volume
1
38.8
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1925751
209378
Dog
inter-alpha-trypsin inhibitor heavy chain family member 5
VGNC:42148
100856779
Horse
inter-alpha-trypsin inhibitor heavy chain family member 5
VGNC:19188
100070032
Cow
inter-alpha-trypsin inhibitor heavy chain family member 5
VGNC:30337
534787
Opossum
inter-alpha-trypsin inhibitor heavy chain family member 5
100011337
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
inter-alpha-trypsin inhibitor heavy chain family member 5
Horse
inter-alpha-trypsin inhibitor heavy chain family member 5
Cow
inter-alpha-trypsin inhibitor heavy chain family member 5
Opossum
inter-alpha-trypsin inhibitor heavy chain family member 5
Publication Statistics
PubMed Score 23.45
PubMed score by year
PubTator Score 16.42
PubTator score by year
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Related Publications
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PMID
Year
Title