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Tbio
DTX2
Probable E3 ubiquitin-protein ligase DTX2

Protein Summary
Description
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324432
  • ENSP00000322885
  • ENSG00000091073
  • ENST00000413936
  • ENSP00000390218
  • ENST00000430490
  • ENSP00000411986
  • ENST00000446820
  • ENSP00000392545

Symbol
  • KIAA1528
  • RNF58
  • RNF58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
transcription factor perturbation
0.8
transcription factor
0.74
gene perturbation
0.73
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
40.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deltex E3 ubiquitin ligase 2
VGNC:13999
100615650
Macaque
deltex E3 ubiquitin ligase 2
719916
Mouse
MGI:1921448
74198
Rat
RGD:1561790
304591
Dog
deltex E3 ubiquitin ligase 2
VGNC:40116
479723
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deltex E3 ubiquitin ligase 2
Macaque
deltex E3 ubiquitin ligase 2
Mouse
Rat
Dog
deltex E3 ubiquitin ligase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86UW9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (51)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH1
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH1
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (55)
1 – 10 of 55
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.966
Data Source:  STRINGDB
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
Score:  0.936
Data Source:  STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
Score:  0.933
Data Source:  STRINGDB
DTX1
Tbio
Family:  Enzyme
Novelty:  0.00972217
Score:  0.933
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.929
Data Source:  STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.929
Data Source:  STRINGDB
PSEN2
Tchem
Family:  Enzyme
Novelty:  0.00112188
Score:  0.925
Data Source:  STRINGDB
PSEN1
Tchem
Family:  Enzyme
Novelty:  0.00024189
Score:  0.923
Data Source:  STRINGDB
APH1A
Tbio
Family:  Enzyme
Novelty:  0.00794922
Score:  0.919
Data Source:  STRINGDB
DNER
Tbio
Novelty:  0.02192523
Score:  0.914
Data Source:  STRINGDB
Publication Statistics
PubMed Score  53.34

PubMed score by year
PubTator Score  22.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer