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Tbio
HAPLN4
Hyaluronan and proteoglycan link protein 4

Protein Summary
Description
Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291481
  • ENSP00000291481
  • ENSG00000187664

Symbol
  • BRAL2
  • KIAA1926
  • BRAL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.71
tissue sample
0.61
PubMedID
0.58
cell type or tissue
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
14
11
20
3.8
99.8
triglyceride measurement
18
10
28
8.2
99.6
total cholesterol measurement
9
6
13
4.4
99.4
apolipoprotein B measurement
2
4
4
98.5
serum alanine aminotransferase measurement
3
4
4
17.9
98.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
20
3.8
99.8
triglyceride measurement
28
8.2
99.6
total cholesterol measurement
13
4.4
99.4
apolipoprotein B measurement
4
98.5
serum alanine aminotransferase measurement
4
17.9
98.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyaluronan and proteoglycan link protein 4
VGNC:2551
468776
Macaque
hyaluronan and proteoglycan link protein 4
719748
Mouse
MGI:2679531
330790
Rat
RGD:1308408
361129
Dog
hyaluronan and proteoglycan link protein 4
VGNC:41595
100686618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyaluronan and proteoglycan link protein 4
Macaque
hyaluronan and proteoglycan link protein 4
Mouse
Rat
Dog
hyaluronan and proteoglycan link protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86UW8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (15)
1 – 10 of 15
TM6SF2
Tbio
Novelty:  0.00965899
Score:  0.937
Data Source:  STRINGDB
TM6SF1
Tdark
Novelty:  0.40815928
Score:  0.93
Data Source:  STRINGDB
PTPRZ1
Tchem
Family:  Enzyme
Novelty:  0.00518159
Score:  0.517
Data Source:  STRINGDB
ADAMTS8
Tbio
Family:  Enzyme
Novelty:  0.04333199
Score:  0.503
Data Source:  STRINGDB
VWA1
Tbio
Novelty:  0.00212445
Score:  0.503
Data Source:  STRINGDB
VWC2L
Tdark
Novelty:  1.5878556
Score:  0.499
Data Source:  STRINGDB
CLSTN3
Tbio
Novelty:  0.10438143
Score:  0.493
Data Source:  STRINGDB
KCNC1
Tclin
Family:  IC
Novelty:  0.00252943
Score:  0.478
Data Source:  STRINGDB
PVALB
Tbio
Novelty:  0.00024439
Score:  0.447
Data Source:  STRINGDB
ADAMTS15
Tbio
Family:  Enzyme
Novelty:  0.09715925
Score:  0.431
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.56

PubMed score by year
PubTator Score  1.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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