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Tbio
N4BP2
NEDD4-binding protein 2

Protein Summary
Description
Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261435
  • ENSP00000261435
  • ENSG00000078177

Symbol
  • B3BP
  • KIAA1413
  • B3BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
transcription factor binding site profile
0.93
histone modification site profile
0.91
microRNA
0.79
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (32)
1 – 10 of 32
FAM98A
Tdark
Novelty:  0.30067413
p_int:  0.99999336
p_ni:  0.00000664
Score:  0.332
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.999989232
p_ni:  0.000010768
Score:  0.188
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.998579519
p_ni:  0.001405701
p_wrong:  0.00001478
Data Source:  BioPlex
ISLR2
Tbio
Novelty:  0.08625149
Score:  0.746
Data Source:  STRINGDB
ZNF770
Tdark
Family:  TF
Novelty:  0.79192428
Score:  0.743
Data Source:  STRINGDB
METAP1
Tchem
Family:  Enzyme
Novelty:  0.01816253
Score:  0.665
Data Source:  STRINGDB
RIF1
Tbio
Novelty:  0.34360368
Score:  0.661
Data Source:  STRINGDB
VPS13B
Tbio
Novelty:  0.02154769
Score:  0.647
Data Source:  STRINGDB
BCL3
Tchem
Novelty:  0.04037329
Score:  0.643
Data Source:  STRINGDB
PDE10A
Tclin
Family:  Enzyme
Novelty:  0.00318215
Score:  0.637
Data Source:  STRINGDB
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
65.5
red blood cell distribution width
1
1
1
38.8
body height
1
1
1
6.4
bitter beverage consumption measurement
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
65.5
red blood cell distribution width
1
38.8
body height
1
6.4
bitter beverage consumption measurement
1
5.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NEDD4 binding protein 2
VGNC:644
471175
Macaque
NEDD4 binding protein 2
700365
Mouse
MGI:2684414
333789
Rat
RGD:1565738
305342
Dog
NEDD4 binding protein 2
VGNC:43597
479101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NEDD4 binding protein 2
Macaque
NEDD4 binding protein 2
Mouse
Rat
Dog
NEDD4 binding protein 2
Publication Statistics
PubMed Score 10.17
PubMed score by year
PubTator Score 4.44
PubTator score by year