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Tbio
SLC51A
Organic solute transporter subunit alpha

Protein Summary
Description
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296327
  • ENSP00000296327
  • ENSG00000163959

Symbol
  • OSTA
  • OSTA
  • OSTalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
cellular component
0.72
tissue sample
0.69
gene perturbation
0.65
PubMedID
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.21   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.21   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0