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Tbio
SLC51A
Organic solute transporter subunit alpha

Protein Summary
Description
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296327
  • ENSP00000296327
  • ENSG00000163959

Symbol
  • OSTA
  • OSTA
  • OSTalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
cellular component
0.72
tissue sample
0.69
gene perturbation
0.65
PubMedID
0.54


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.29   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.29   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
4
4
96.1
mean corpuscular volume
3
4
4
94.4
red blood cell distribution width
2
3
3
91.8
mean corpuscular hemoglobin
2
2
2
82.9
mean platelet volume
2
2
2
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
96.1
mean corpuscular volume
4
94.4
red blood cell distribution width
3
91.8
mean corpuscular hemoglobin
2
82.9
mean platelet volume
2
81.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 51 alpha subunit
VGNC:8007
460958
Macaque
solute carrier family 51 alpha subunit
711340
Mouse
MGI:2146634
106407
Rat
RGD:1311100
303879
Dog
solute carrier family 51 alpha subunit
VGNC:46440
609420
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 51 alpha subunit
Macaque
solute carrier family 51 alpha subunit
Mouse
Rat
Dog
solute carrier family 51 alpha subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86UW1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (76)
1 – 10 of 76
ANO6
Tbio
Family:  IC
Novelty:  0.01288434
p_int:  0.98942192
p_ni:  0.010578068
p_wrong:  1.1e-8
Score:  0.178
Data Source:  BioPlex,STRINGDB
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.898379042
p_ni:  0.101603827
p_wrong:  0.000017131
Score:  0.183
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.896111697
p_ni:  0.103888303
Data Source:  BioPlex
FAM8A1
Tbio
Novelty:  0.08206001
p_int:  0.779251604
p_ni:  0.220748396
Score:  0.653
Data Source:  BioPlex,STRINGDB
LNPK
Tbio
Novelty:  0.07736762
p_int:  0.752354789
p_ni:  0.247644389
p_wrong:  8.22e-7
Score:  0.157
Data Source:  BioPlex,STRINGDB
SLC51B
Tbio
Family:  Transporter
Novelty:  0.03325003
Score:  0.991
Data Source:  STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.823
Data Source:  STRINGDB
SLC10A2
Tclin
Family:  Transporter
Novelty:  0.0036213
Score:  0.809
Data Source:  STRINGDB
ABCC3
Tbio
Family:  Transporter
Novelty:  0.00260166
Score:  0.767
Data Source:  STRINGDB
ZDHHC19
Tdark
Family:  Enzyme
Novelty:  0.35398354
Score:  0.727
Data Source:  STRINGDB
Publication Statistics
PubMed Score  46.29

PubMed score by year
PubTator Score  33.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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