Tbio USP48 Ubiquitin carboxyl-terminal hydrolase 48

Protein Summary

Description

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86UV5
• B7ZKS7
• Q2M3I4
• Q5SZI4
• Q5T3T5
• Q6NX53
• Q8N3F6
• Q96F64
• Q96IQ3
• Q9H5N3
• Q9H5T7
• Q9NUJ6
• Q9NXR0

Gene Name

• USP48

Ensembl ID

• ENST00000308271
• ENSP00000309262
• ENSG00000090686
• ENST00000400301
• ENSP00000383157
• ENST00000421625
• ENSP00000406256
• ENST00000529637
• ENSP00000431949

Symbol

• USP31
• USP31
• RAP1GA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor binding site profile	0.96
disease perturbation	0.95
transcription factor perturbation	0.94
interacting protein	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0