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Tbio
USP48
Ubiquitin carboxyl-terminal hydrolase 48

Protein Summary
Description
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308271
  • ENSP00000309262
  • ENSG00000090686
  • ENST00000400301
  • ENSP00000383157
  • ENST00000421625
  • ENSP00000406256
  • ENST00000529637
  • ENSP00000431949

Symbol
  • USP31
  • USP31
  • RAP1GA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor binding site profile
0.96
disease perturbation
0.95
transcription factor perturbation
0.94
interacting protein
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.74   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.74   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (59)
1 – 10 of 59
FMNL2
Tbio
Novelty:  0.03453161
p_int:  0.999938366
p_ni:  7.73e-7
p_wrong:  0.000060861
Data Source:  BioPlex
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.999733195
p_ni:  0.000266805
Score:  0.185
Data Source:  BioPlex,STRINGDB
NR1D2
Tchem
Family:  NR
Novelty:  0.01394655
p_int:  0.999335144
p_ni:  0.000595618
p_wrong:  0.000069238
Score:  0.19
Data Source:  BioPlex,STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.99435117
p_ni:  0.00564883
Score:  0.575
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.992737392
p_ni:  0.007262607
p_wrong:  1e-9
Score:  0.428
Data Source:  BioPlex,STRINGDB
HIST1H2BJ
Tbio
Novelty:  0.14308844
p_int:  0.988848628
p_ni:  0.010004284
p_wrong:  0.001147089
Score:  0.286
Data Source:  BioPlex,STRINGDB
PXK
Tbio
Family:  Kinase
Novelty:  0.02316511
p_int:  0.987650487
p_ni:  0.012349513
Score:  0.262
Data Source:  BioPlex,STRINGDB
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.985363731
p_ni:  0.014636262
p_wrong:  7e-9
Score:  0.582
Data Source:  BioPlex,STRINGDB
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.752609239
p_ni:  0.000023055
p_wrong:  0.247367706
Score:  0.208
Data Source:  BioPlex,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.901
Data Source:  Reactome,STRINGDB
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
3
9
94.7
alkaline phosphatase measurement
1
2
2
90.8
reticulocyte measurement
3
2
5
90
heel bone mineral density
2
2
3
83.3
testosterone measurement
1
1
1
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
94.7
alkaline phosphatase measurement
2
90.8
reticulocyte measurement
5
90
heel bone mineral density
3
83.3
testosterone measurement
1
65.3
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 48
VGNC:10900
456602
Macaque
ubiquitin specific peptidase 48
707110
Mouse
MGI:2158502
170707
Rat
RGD:735213
362636
Dog
ubiquitin specific peptidase 48
VGNC:48199
478198
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 48
Macaque
ubiquitin specific peptidase 48
Mouse
Rat
Dog
ubiquitin specific peptidase 48
Publication Statistics
PubMed Score 14.74
PubMed score by year
PubTator Score 5.74
PubTator score by year