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Tbio
BCL9L
B-cell CLL/lymphoma 9-like protein

Protein Summary
Description
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334801
  • ENSP00000335320
  • ENSG00000186174

Symbol
  • DLNB11
  • B9L
  • BCL9-2
  • DLNB11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
biological process
0.81
transcription factor
0.81
transcription factor binding site profile
0.77
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.88   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.88   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.963
Data Source:  Reactome,STRINGDB
PYGO2
Tbio
Family:  Epigenetic
Novelty:  0.04196406
Score:  0.956
Data Source:  Reactome,STRINGDB
PYGO1
Tdark
Family:  Epigenetic
Novelty:  0.18099753
Score:  0.956
Data Source:  Reactome,STRINGDB
TCF7L1
Tbio
Family:  TF
Novelty:  0.03807371
Score:  0.946
Data Source:  STRINGDB
TCF7L2
Tbio
Family:  TF
Novelty:  0.00178694
Score:  0.932
Data Source:  Reactome,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
Score:  0.928
Data Source:  STRINGDB
TCF7
Tbio
Family:  TF
Novelty:  0.00846497
Score:  0.928
Data Source:  STRINGDB
APC
Tchem
Novelty:  0.00168376
Score:  0.923
Data Source:  STRINGDB
BCL9
Tbio
Novelty:  0.01853613
Score:  0.922
Data Source:  STRINGDB
BTRC
Tbio
Novelty:  0.00293475
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
4
0
1.1
91.4
4
3
2
1.1
81.5
3
2
0
1.1
76.4
primary biliary cirrhosis
3
3
0
1.4
70.5
3
2
2
1.1
69.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.4
2
1.1
81.5
0
1.1
76.4
primary biliary cirrhosis
0
1.4
70.5
2
1.1
69.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B-cell CLL/lymphoma 9 like
451596
Macaque
B-cell CLL/lymphoma 9 like
100428938
Mouse
MGI:1933114
80288
Rat
RGD:1309096
300673
Dog
B-cell CLL/lymphoma 9 like
489377
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B-cell CLL/lymphoma 9 like
Macaque
B-cell CLL/lymphoma 9 like
Mouse
Rat
Dog
B-cell CLL/lymphoma 9 like
Publication Statistics
PubMed Score 19.88
PubMed score by year
PubTator Score 8.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title