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Tbio
NLRX1
NLR family member X1

Protein Summary
Description
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292199
  • ENSP00000292199
  • ENSG00000160703
  • ENST00000409109
  • ENSP00000387334
  • ENST00000409265
  • ENSP00000386858
  • ENST00000409991
  • ENSP00000386851
  • ENST00000525863
  • ENSP00000433442

Symbol
  • NOD26
  • NOD5
  • NOD9
  • NOD5
  • NOD9
  • NOD26
  • DLNB26
  • CLR11.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
molecular function
0.76
kinase perturbation
0.71
cellular component
0.68
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.31   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.31   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (79)
1 – 10 of 79
PVR
Tbio
Novelty:  0.00215811
p_int:  0.999976427
p_ni:  0.000023573
Data Source:  BioPlex
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
p_int:  0.99985321
p_ni:  0.00014679
Score:  0.183
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.987825975
p_ni:  0.012174025
Data Source:  BioPlex
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.97952601
p_ni:  0.02047399
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.978084725
p_ni:  0.021915275
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.975511432
p_ni:  0.024488568
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.916074265
p_ni:  0.083925735
Data Source:  BioPlex
CREB3
Tbio
Family:  TF
Novelty:  0.00424318
p_int:  0.904533467
p_ni:  0.095466533
Score:  0.179
Data Source:  BioPlex,STRINGDB
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.88823338
p_ni:  0.11176662
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.886289893
p_ni:  0.113710106
p_wrong:  1e-9
Data Source:  BioPlex
Pathways (10)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Negative regulators of DDX58/IFIH1 signaling
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Negative regulators of DDX58/IFIH1 signaling
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
6
6.3
98.8
platelet crit
2
5
6
98.2
mean reticulocyte volume
1
2
2
94.6
lymphocyte count
3
3
3
88.2
mean corpuscular volume
1
2
2
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
6.3
98.8
platelet crit
6
98.2
mean reticulocyte volume
2
94.6
lymphocyte count
3
88.2
mean corpuscular volume
2
81
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NLR family member X1
VGNC:12657
451605
Macaque
NLR family member X1
703981
Mouse
MGI:2429611
270151
Rat
RGD:1311293
315599
Dog
NLR family member X1
VGNC:43853
489370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NLR family member X1
Macaque
NLR family member X1
Mouse
Rat
Dog
NLR family member X1
Publication Statistics
PubMed Score 132.31
PubMed score by year
PubTator Score 26.32
PubTator score by year