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Tbio
PDZD3
Na(+)/H(+) exchange regulatory cofactor NHE-RF4

Protein Summary
Description
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322712
  • ENSP00000327107
  • ENSG00000172367
  • ENST00000355547
  • ENSP00000347742
  • ENST00000531114
  • ENSP00000431164

Symbol
  • IKEPP
  • NHERF4
  • PDZK2
  • IKEPP
  • PDZK2
  • NHERF4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
tissue
0.67
PubMedID
0.58
biological process
0.54
cellular component
0.51


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 3
VGNC:1089
466803
Macaque
PDZ domain containing 3
704100
Mouse
MGI:2429554
170761
Rat
RGD:1559807
500986
Dog
PDZ domain containing 3
VGNC:44400
610585
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 3
Macaque
PDZ domain containing 3
Mouse
Rat
Dog
PDZ domain containing 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86UT5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Intestinal infectious diseases
Reactome
Uptake and actions of bacterial toxins
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Intestinal infectious diseases
Uptake and actions of bacterial toxins
Protein-Protein Interactions (30)
1 – 10 of 30
GUCY2C
Tclin
Family: Kinase
Novelty: 0.00209733
Score: 0.87
Data Source: STRINGDB
SLC34A1
Tbio
Family: Transporter
Novelty: 0.00805088
Score: 0.768
Data Source: STRINGDB
SLC9A3
Tclin
Family: Transporter
Novelty: 0.00146466
Score: 0.758
Data Source: STRINGDB
GUCA2B
Tbio
Family: Enzyme
Novelty: 0.02002363
Score: 0.69
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.681
Data Source: STRINGDB
P2RY4
Tchem
Family: GPCR
Novelty: 0.00903213
Score: 0.667
Data Source: STRINGDB
GUCA2A
Tbio
Novelty: 0.00856211
Score: 0.661
Data Source: STRINGDB
SLC26A3
Tbio
Family: Transporter
Novelty: 0.00157687
Score: 0.643
Data Source: STRINGDB
TRPV6
Tchem
Family: IC
Novelty: 0.00383629
Score: 0.625
Data Source: STRINGDB
MAPKAPK5
Tchem
Family: Kinase
Novelty: 0.01349079
Score: 0.589
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.92

PubMed score by year
PubTator Score  7.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer