PDZD3
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
Protein Summary
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
- ENST00000322712
- ENSP00000327107
- ENSG00000172367
- ENST00000355547
- ENSP00000347742
- ENST00000531114
- ENSP00000431164
- IKEPP
- NHERF4
- PDZK2
- IKEPP
- PDZK2
- NHERF4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.74 | ||
tissue | 0.67 | ||
PubMedID | 0.58 | ||
biological process | 0.54 | ||
cellular component | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.02 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.02 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (30)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Infectious disease | ||||
Reactome | Intestinal infectious diseases | ||||
Reactome | Uptake and actions of bacterial toxins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Infectious disease | ||||
Intestinal infectious diseases | ||||
Uptake and actions of bacterial toxins | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 5 | 5 | 6 | 6.3 | 98.8 | ||||
platelet crit | 2 | 4 | 5 | 97.4 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 94.6 | |||||
lymphocyte count | 3 | 3 | 3 | 88.2 | |||||
mean corpuscular volume | 1 | 2 | 2 | 81 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 6 | 6.3 | 98.8 | ||||
platelet crit | 5 | 97.4 | |||||
mean reticulocyte volume | 2 | 94.6 | |||||
lymphocyte count | 3 | 88.2 | |||||
mean corpuscular volume | 2 | 81 | |||||
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IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | PDZ domain containing 3 | VGNC:1089 | 466803 | |||||
Macaque | PDZ domain containing 3 | 704100 | ||||||
Mouse | MGI:2429554 | 170761 | ||||||
Rat | RGD:1559807 | 500986 | ||||||
Dog | PDZ domain containing 3 | VGNC:44400 | 610585 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | PDZ domain containing 3 | |||||
Macaque | PDZ domain containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | PDZ domain containing 3 | |||||
Publication Statistics
PubMed Score 10.02
PubMed score by year
PubTator Score 7.85
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (4)
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0 of 0
PMID | Year | Title |
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