Tbio PDZD3 Na(+)/H(+) exchange regulatory cofactor NHE-RF4

Protein Summary

Description

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q86UT5
• Q8N6R4
• Q8NAW7
• Q8NEX7
• Q9H5Z3
• NHERF-4

Gene Name

• PDZD3

Ensembl ID

• ENST00000322712
• ENSP00000327107
• ENSG00000172367
• ENST00000355547
• ENSP00000347742
• ENST00000531114
• ENSP00000431164

Symbol

• IKEPP
• NHERF4
• PDZK2
• IKEPP
• PDZK2
• NHERF4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
tissue	0.67
PubMedID	0.58
biological process	0.54
cellular component	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0