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Tbio
SMG6
Telomerase-binding protein EST1A

Protein Summary
Description
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). Plays a role in nonsense-mediated mRNA decay (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggerin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263073
  • ENSP00000263073
  • ENSG00000070366
  • ENST00000354901
  • ENSP00000346977
  • ENST00000536871
  • ENSP00000440283

Symbol
  • C17orf31
  • EST1A
  • KIAA0732
  • EST1A
  • SMG-6
  • C17orf31
  • hSMG5/7a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.81
histone modification site profile
0.81
protein domain
0.73
transcription factor binding site profile
0.72
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.53   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.53   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (217)
1 – 10 of 217
C2orf68
Tdark
Novelty: 0.31818182
p_int: 0.999999947
p_ni: 5.3e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
FAM221B
Tdark
p_int: 0.999996443
p_ni: 0.000003557
Score: 0.214
Data Source: BioPlex,STRINGDB
SPATA1
Tdark
p_int: 0.999996177
p_ni: 0.000003823
Data Source: BioPlex
HAO2
Tchem
Family: Enzyme
Novelty: 0.05085077
p_int: 0.999993395
p_ni: 0.000006598
p_wrong: 7e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
LPIN3
Tbio
Family: Enzyme
Novelty: 0.02517952
p_int: 0.998139935
p_ni: 0.001860063
p_wrong: 2e-9
Score: 0.245
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00171173
p_int: 0.994595129
p_ni: 0.005404869
p_wrong: 2e-9
Data Source: BioPlex
PSG1
Tbio
Novelty: 0.02762481
p_int: 0.969157313
p_ni: 0.030823747
p_wrong: 0.00001894
Score: 0.196
Data Source: BioPlex,STRINGDB
UPF1
Tbio
Novelty: 0.00380485
Score: 0.998
Data Source: STRINGDB
UPF2
Tbio
Novelty: 0.01490824
Score: 0.995
Data Source: STRINGDB
UPF3B
Tbio
Novelty: 0.04266125
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.53

PubMed score by year
PubTator Score  26.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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