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Tbio
ABCA13
ATP-binding cassette sub-family A member 13

Protein Summary
Description
In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated.[provided by RefSeq, Mar 2009]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
trait
0.86
tissue sample
0.81
gene perturbation
0.71
phenotype
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.15   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.15   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Immune System (R-HSA-168256)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (110)
1 – 10 of 110
CEACAM8
Tbio
Novelty: 0.00515482
Score: 0.919
Data Source: STRINGDB
CEACAM6
Tbio
Novelty: 0.0037385
Score: 0.913
Data Source: STRINGDB
BRI3
Tbio
Novelty: 0.02014324
Score: 0.909
Data Source: STRINGDB
STOM
Tbio
Novelty: 0.00472127
Score: 0.907
Data Source: STRINGDB
CD68
Tbio
Novelty: 0.00026143
Score: 0.907
Data Source: STRINGDB
SNAP29
Tbio
Novelty: 0.02549569
Score: 0.906
Data Source: STRINGDB
MAGT1
Tbio
Novelty: 0.02562036
Score: 0.906
Data Source: STRINGDB
TMEM30A
Tbio
Novelty: 0.05869796
Score: 0.906
Data Source: STRINGDB
ATP8A1
Tbio
Family: Transporter
Novelty: 0.02501412
Score: 0.906
Data Source: STRINGDB
VNN1
Tchem
Family: Enzyme
Novelty: 0.01845634
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.15

PubMed score by year