Tbio ABCA13 ATP-binding cassette sub-family A member 13

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family A Member 13

Protein Summary

Description

In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated.[provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q86UQ4
• K9LC76
• K9LC79
• K9LCX7
• K9LDK8
• K9LDY4
• Q6ZTT7
• Q86WI2
• Q8N248

Gene Name

• ABCA13

Ensembl ID

• ENST00000417403
• ENSP00000409268
• ENSG00000179869

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
trait	0.86
tissue sample	0.81
gene perturbation	0.71
phenotype	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.15   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.15   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (4)

Reactome (3)

KEGG (1)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (10)

Functions (3)

Components (5)

Processes (2)

Items per page:

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1 – 3 of 3

GO Term	Evidence	Assigned by
ATPase activity, coupled to transmembrane movement of substances	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
lipid transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (110)

Explore Interacting Targets

1 – 10 of 110

• See Interactions on String-DB

CEACAM8

Tbio

Novelty: 0.00515482

Score: 0.919

Data Source: STRINGDB

CEACAM6

Tbio

Novelty: 0.0037385

Score: 0.913

Data Source: STRINGDB

BRI3

Tbio

Novelty: 0.02014324

Score: 0.909

Data Source: STRINGDB

STOM

Tbio

Novelty: 0.00472127

Score: 0.907

Data Source: STRINGDB

CD68

Tbio

Novelty: 0.00026143

Score: 0.907

Data Source: STRINGDB

SNAP29

Tbio

Novelty: 0.02549569

Score: 0.906

Data Source: STRINGDB

MAGT1

Tbio

Novelty: 0.02562036

Score: 0.906

Data Source: STRINGDB

TMEM30A

Tbio

Novelty: 0.05869796

Score: 0.906

Data Source: STRINGDB

ATP8A1

Tbio

Family: Transporter

Novelty: 0.02501412

Score: 0.906

Data Source: STRINGDB

VNN1

Tchem

Family: Enzyme

Novelty: 0.01845634

Score: 0.906

Data Source: STRINGDB

Publication Statistics

PubMed Score  16.15

PubMed score by year