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Tbio
GTF2IRD2
General transcription factor II-I repeat domain-containing protein 2A

Protein Summary
Description
This gene is one of several closely related genes on chromosome 7 encoding proteins containing helix-loop-helix motifs. These proteins may function as regulators of transcription. The encoded protein is unique in that its C-terminus is derived from CHARLIE8 transposable element sequence. This gene is located in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, and loss of this locus may contribute to the cognitive phenotypes observed in this disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
cell type or tissue
0.74
transcription factor perturbation
0.68
tissue sample
0.58
transcription factor binding site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.94   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.94   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (18)
1 – 10 of 18
GTF2IRD2B
Tbio
Family:  TF
Novelty:  0.14868633
p_int:  1
Score:  0.938
Data Source:  BioPlex,STRINGDB
NCF1
Tbio
Novelty:  0.00120288
Score:  0.641
Data Source:  STRINGDB
ELN
Tbio
Novelty:  0.00026801
Score:  0.527
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.47
Data Source:  STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.469
Data Source:  STRINGDB
PRRC2B
Tdark
Novelty:  0.28608235
Score:  0.467
Data Source:  STRINGDB
ZNF449
Tdark
Family:  TF
Novelty:  0.71740836
Score:  0.465
Data Source:  STRINGDB
SEC14L5
Tdark
Novelty:  0.32185533
Score:  0.46
Data Source:  STRINGDB
POM121L2
Tdark
Novelty:  0.55673473
Score:  0.442
Data Source:  STRINGDB
SPDYE1
Tdark
Novelty:  0.46460265
Score:  0.44
Data Source:  STRINGDB
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
2.1
84.6
red blood cell distribution width
4
1
4
80.4
mathematical ability
2
2
2
63.6
heel bone mineral density
2
2
2
59.4
lymphocyte percentage of leukocytes
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.1
84.6
red blood cell distribution width
4
80.4
mathematical ability
2
63.6
heel bone mineral density
2
59.4
lymphocyte percentage of leukocytes
1
59
Find similar targets by:
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2149780
114674
Horse
general transcription factor II-I repeat domain-containing protein 2
100062625
Cow
GTF2I repeat domain containing 2
539745
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
general transcription factor II-I repeat domain-containing protein 2
Cow
GTF2I repeat domain containing 2
Publication Statistics
PubMed Score 4.94
PubMed score by year
PubTator Score 6.33
PubTator score by year