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Tbio
RTN4RL2
Reticulon-4 receptor-like 2

Protein Summary
Description
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335099
  • ENSP00000335397
  • ENSG00000186907
  • ENST00000395120
  • ENSP00000378552

Symbol
  • NGRH1
  • NGRL3
  • NgR2
  • NGRH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
histone modification site profile
0.65
transcription factor binding site profile
0.62
tissue sample
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (93)
1 – 10 of 93
LCN6
Tbio
Novelty: 0.06664903
p_int: 0.999687921
p_ni: 0.000203472
p_wrong: 0.000108608
Data Source: BioPlex
NRROS
Tbio
Novelty: 0.15009747
p_int: 0.994532172
p_ni: 0.000722031
p_wrong: 0.004745797
Score: 0.195
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032884
p_int: 0.993900261
p_ni: 0.000831052
p_wrong: 0.005268687
Score: 0.22
Data Source: BioPlex,STRINGDB
IL20
Tbio
Novelty: 2
p_int: 0.881585663
p_ni: 0.002716177
p_wrong: 0.11569816
Data Source: BioPlex
NTNG1
Tbio
Novelty: 0.06726353
Score: 0.914
Data Source: STRINGDB
CNTN5
Tbio
Novelty: 0.00997112
Score: 0.911
Data Source: STRINGDB
CNTN3
Tbio
Novelty: 0.0030855
Score: 0.91
Data Source: STRINGDB
RTN4RL1
Tbio
Novelty: 0.15789626
Score: 0.91
Data Source: STRINGDB
CNTN4
Tbio
Novelty: 0.02725707
Score: 0.91
Data Source: STRINGDB
NTNG2
Tbio
Novelty: 0.04650385
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.21

PubMed score by year
PubTator Score  9.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer