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Tbio
MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Protein Summary
Description
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354212
  • ENSP00000346151
  • ENSG00000187391
  • ENST00000419488
  • ENSP00000405766

Symbol
  • ACVRINP1
  • AIP1
  • KIAA0705
  • AIP1
  • AIP-1
  • ARIP1
  • SSCAM
  • MAGI-2
  • NPHS15
  • ACVRIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.92
protein domain
0.92
histone modification site profile
0.72
phenotype
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.84   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.84   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
3
4
95.9
Moyamoya disease
1
1
0
1.6
82.9
smoking status measurement
2
3
4
79.5
2
2
0
1.1
66.2
1
1
1
43
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
95.9
Moyamoya disease
0
1.6
82.9
smoking status measurement
4
79.5
0
1.1
66.2
1
43
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane associated guanylate kinase, WW and PDZ domain containing 2
VGNC:8699
463498
Macaque
membrane associated guanylate kinase, WW and PDZ domain containing 2
693359
Mouse
MGI:1354953
50791
Rat
RGD:621855
113970
Dog
membrane associated guanylate kinase, WW and PDZ domain containing 2
VGNC:42928
475904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane associated guanylate kinase, WW and PDZ domain containing 2
Macaque
membrane associated guanylate kinase, WW and PDZ domain containing 2
Mouse
Rat
Dog
membrane associated guanylate kinase, WW and PDZ domain containing 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86UL8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Nephrin family interactions
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Nephrin family interactions
Gene Ontology Terms (34)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (82)
1 – 10 of 82
RHBDL1
Tdark
Family: Enzyme
Novelty: 0.63616927
p_int: 0.976936011
p_ni: 4.6e-8
p_wrong: 0.023063943
Score: 0.696
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.946
Data Source: STRINGDB
NPHS1
Tbio
Novelty: 0.00104742
Score: 0.944
Data Source: Reactome,STRINGDB
RAPGEF2
Tbio
Novelty: 0.03353183
Score: 0.938
Data Source: STRINGDB
KIRREL1
Tbio
Novelty: 0.03216031
Score: 0.935
Data Source: Reactome,STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
Score: 0.907
Data Source: STRINGDB
MAGI3
Tbio
Family: Enzyme
Novelty: 0.03968945
Score: 0.816
Data Source: STRINGDB
MAGI1
Tbio
Family: Enzyme
Novelty: 0.06837323
Score: 0.816
Data Source: STRINGDB
RAPGEF6
Tbio
Novelty: 0.07979293
Score: 0.804
Data Source: STRINGDB
MAST1
Tchem
Family: Kinase
Novelty: 0.28068951
Score: 0.74
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.84

PubMed score by year
PubTator Score  43.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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