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Tbio
ZNF598
E3 ubiquitin-protein ligase ZNF598

Protein Summary
Description
E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mamm ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431526
  • ENSP00000411409
  • ENSG00000167962

Symbol
  • HEL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
cell line
0.69
disease perturbation
0.68
transcription factor binding site profile
0.61
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
POC1B
Tbio
Novelty:  0.09023863
p_int:  0.999999453
p_ni:  5.47e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999620565
p_ni:  0.000379435
Data Source:  BioPlex
STK25
Tchem
Family:  Kinase
Novelty:  0.03229688
p_int:  0.997497902
p_ni:  0.00250066
p_wrong:  0.000001438
Score:  0.249
Data Source:  BioPlex,STRINGDB
PAK5
Tchem
Family:  Kinase
Novelty:  0.02138632
p_int:  0.984982642
p_ni:  0.014997831
p_wrong:  0.000019527
Score:  0.206
Data Source:  BioPlex,STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.843
Data Source:  STRINGDB
DIS3L
Tbio
Family:  Enzyme
Novelty:  0.12886408
Score:  0.82
Data Source:  STRINGDB
TPX2
Tbio
Novelty:  0.00435921
Score:  0.816
Data Source:  STRINGDB
GIGYF2
Tchem
Novelty:  0.02395014
Score:  0.813
Data Source:  STRINGDB
C8orf34
Tdark
Novelty:  0.25922336
Score:  0.747
Data Source:  STRINGDB
ANKUB1
Tdark
Novelty:  1.72920371
Score:  0.729
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
92
serum gamma-glutamyl transferase measurement
1
1
1
81
glomerular filtration rate
2
2
2
78.7
2
3
0
1.1
77.8
hemoglobin measurement
2
1
2
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
92
serum gamma-glutamyl transferase measurement
1
81
glomerular filtration rate
2
78.7
0
1.1
77.8
hemoglobin measurement
2
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2670965
213753
Rat
RGD:1304900
287119
Dog
zinc finger protein 598
VGNC:48771
490061
Horse
zinc finger protein 598
VGNC:25353
100068083
Opossum
zinc finger protein 598
100012340
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
zinc finger protein 598
Horse
zinc finger protein 598
Opossum
zinc finger protein 598
Publication Statistics
PubMed Score 17.35
PubMed score by year
PubTator Score 2.98
PubTator score by year
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Related Publications
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PMID
Year
Title