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Tbio
ABCA12
ATP-binding cassette sub-family A member 12

Protein Summary
Description
Probable transporter involved in lipid homeostasis. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272895
  • ENSP00000272895
  • ENSG00000144452
  • ENST00000389661
  • ENSP00000374312

Symbol
  • ABC12
  • LI2
  • ICR2B
  • ARCI4A
  • ARCI4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cell type or tissue
0.85
protein domain
0.85
cellular component
0.71
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.98   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.98   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B
Reactome
Disease
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B
Disease
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (53)
1 – 10 of 53
NIPAL4
Tbio
Novelty: 0.05110099
Score: 0.824
Data Source: STRINGDB
CYP4F22
Tbio
Novelty: 0.01907586
Score: 0.816
Data Source: STRINGDB
ALOXE3
Tbio
Family: Enzyme
Novelty: 0.02560954
Score: 0.806
Data Source: STRINGDB
TGM1
Tchem
Family: Enzyme
Novelty: 0.00103799
Score: 0.802
Data Source: STRINGDB
CST6
Tbio
Novelty: 0.02811473
Score: 0.8
Data Source: STRINGDB
ALOX12B
Tbio
Family: Enzyme
Novelty: 0.02778552
Score: 0.768
Data Source: STRINGDB
PNPLA1
Tbio
Family: Enzyme
Novelty: 0.03127922
Score: 0.764
Data Source: STRINGDB
LIPN
Tbio
Family: Enzyme
Novelty: 0.00135912
Score: 0.708
Data Source: STRINGDB
CERS3
Tbio
Family: TF
Novelty: 0.038629
Score: 0.672
Data Source: STRINGDB
NR1H2
Tchem
Family: NR
Novelty: 0.01296966
Score: 0.632
Data Source: STRINGDB
Publication Statistics
PubMed Score  174.98

PubMed score by year
PubTator Score  236.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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