Tbio TSPAN33 Tetraspanin-33

Protein Summary

Description

Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).

Uniprot Accession IDs

• Q86UF1
• Tspan-33

Gene Name

• TSPAN33

Ensembl ID

• ENST00000486685
• ENSP00000483872
• ENSG00000158457

Symbol

• PEN
• PEN
• PEN.
• TSPAN-33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.73
transcription factor binding site profile	0.61
microRNA	0.56
transcription factor	0.55
tissue sample	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0