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Tbio
TSPAN33
Tetraspanin-33

Protein Summary
Description
Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000486685
  • ENSP00000483872
  • ENSG00000158457

Symbol
  • PEN
  • PEN
  • PEN.
  • TSPAN-33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
transcription factor binding site profile
0.61
microRNA
0.56
transcription factor
0.55
tissue sample
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.54   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.54   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (27)
1 – 10 of 27
PLEKHA7
Tbio
Novelty:  0.05239328
p_int:  1
Score:  0.596
Data Source:  BioPlex,STRINGDB
PDZD11
Tbio
Novelty:  0.09750858
p_int:  0.99977051
p_ni:  0.00022949
Score:  0.455
Data Source:  BioPlex,STRINGDB
EZR
Tbio
Novelty:  0.00115353
p_int:  0.778813037
p_ni:  0.221186963
Score:  0.417
Data Source:  BioPlex,STRINGDB
MSN
Tbio
Novelty:  0.00178275
p_int:  0.755716712
p_ni:  0.244283288
Score:  0.58
Data Source:  BioPlex,STRINGDB
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
Score:  0.728
Data Source:  STRINGDB
ADAM10
Tchem
Family:  Enzyme
Novelty:  0.00160129
Score:  0.722
Data Source:  Reactome,STRINGDB
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.707
Data Source:  STRINGDB
TMEM182
Tdark
Novelty:  0.35321541
Score:  0.675
Data Source:  STRINGDB
TM6SF1
Tdark
Novelty:  0.40815928
Score:  0.646
Data Source:  STRINGDB
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
Score:  0.641
Data Source:  STRINGDB
Pathways (2)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.6
80.4
1
1
0
1.7
79.5
urate measurement
2
2
2
59.6
1
1
0
2.8
51.7
glomerular filtration rate
1
1
0
6.1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
80.4
0
1.7
79.5
urate measurement
2
59.6
0
2.8
51.7
glomerular filtration rate
0
6.1
5.3
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tetraspanin 33
703028
Mouse
MGI:1919012
232670
Rat
RGD:1560915
500065
Dog
tetraspanin 33
VGNC:47922
475198
Cow
tetraspanin 33
VGNC:36438
539284
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tetraspanin 33
Mouse
Rat
Dog
tetraspanin 33
Cow
tetraspanin 33
Publication Statistics
PubMed Score 5.54
PubMed score by year
PubTator Score 19.97
PubTator score by year