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Tbio
MTDH
Protein LYRIC

Protein Summary
Description
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336273
  • ENSP00000338235
  • ENSG00000147649

Symbol
  • AEG1
  • LYRIC
  • 3D3
  • AEG1
  • AEG-1
  • LYRIC
  • LYRIC/3D3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
transcription factor perturbation
1
kinase perturbation
0.99
interacting protein
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.75   (req: < 5)
Gene RIFs: 237   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.75   (req: >= 5)
Gene RIFs: 237   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
91.9
mean corpuscular hemoglobin concentration
1
1
1
79.9
mean corpuscular hemoglobin
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
91.9
mean corpuscular hemoglobin concentration
1
79.9
mean corpuscular hemoglobin
1
6.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metadherin
VGNC:841
472825
Macaque
metadherin
702410
Mouse
MGI:1914404
67154
Rat
RGD:620992
170910
Dog
metadherin
VGNC:43462
612147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metadherin
Macaque
metadherin
Mouse
Rat
Dog
metadherin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86UE4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated targets of C-MYC transcriptional activation
Name
Explore in Pharos
Explore in Source
Validated targets of C-MYC transcriptional activation
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (66)
1 – 10 of 66
SNN
Tdark
Novelty: 0.02279983
p_int: 0.999972217
p_ni: 0.000027783
Score: 0.309
Data Source: BioPlex,STRINGDB
SND1
Tbio
Family: Epigenetic
Novelty: 0.00949997
p_int: 0.999621299
p_ni: 0.000378701
Score: 0.977
Data Source: BioPlex,STRINGDB
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.999343497
p_ni: 0.000656503
Score: 0.209
Data Source: BioPlex,STRINGDB
MTUS2
Tbio
Novelty: 0.13504593
p_int: 0.950076791
p_ni: 0.049923208
Score: 0.175
Data Source: BioPlex,STRINGDB
NR2E1
Tbio
Family: NR
Novelty: 0.0184868
p_int: 0.931013378
p_ni: 0.068986622
Score: 0.239
Data Source: BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.870209885
p_ni: 0.129779984
p_wrong: 0.000010131
Data Source: BioPlex
HEATR3
Tbio
Novelty: 0.08367436
p_int: 0.831187928
p_ni: 0.168787119
p_wrong: 0.000024953
Data Source: BioPlex
ZYG11B
Tbio
Novelty: 0.14657862
p_int: 0.819534656
p_ni: 0.180465344
Score: 0.183
Data Source: BioPlex,STRINGDB
CRISP3
Tbio
Novelty: 0.017452
Score: 0.748
Data Source: STRINGDB
SLC1A2
Tchem
Family: Transporter
Novelty: 0.00086733
Score: 0.746
Data Source: STRINGDB
Publication Statistics
PubMed Score  428.75

PubMed score by year
PubTator Score  237.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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