Tbio MTDH Protein LYRIC

Protein Summary

Description

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Uniprot Accession IDs

• Q86UE4
• Q05DH2
• Q52QU9
• Q6PK07
• Q8TCX3

Gene Name

• MTDH

Ensembl ID

• ENST00000336273
• ENSP00000338235
• ENSG00000147649

Symbol

• AEG1
• LYRIC
• 3D3
• AEG1
• AEG-1
• LYRIC
• LYRIC/3D3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	1
transcription factor perturbation	1
kinase perturbation	0.99
interacting protein	0.97

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.87   (req: < 5)

Gene RIFs: 278   (req: <= 3)

Antibodies: 340   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.87   (req: >= 5)

Gene RIFs: 278   (req: > 3)

Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0