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Tdark
TMEM135
Transmembrane protein 135

Protein Summary
Description
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305494
  • ENSP00000306344
  • ENSG00000166575
  • ENST00000340353
  • ENSP00000345513

Symbol
  • PMP52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.9
histone modification site profile
0.8
microRNA
0.75
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (31)
1 – 10 of 31
SMPD3
Tbio
Family: Enzyme
Novelty: 0.01367455
p_int: 0.990423176
p_ni: 2.3e-8
p_wrong: 0.009576801
Score: 0.622
Data Source: BioPlex,STRINGDB
BIRC6
Tbio
Novelty: 0.01472975
p_int: 0.927218515
p_ni: 0.072781485
Data Source: BioPlex
ZCCHC10
Tdark
Novelty: 0.48780488
Score: 0.695
Data Source: STRINGDB
CTDSPL2
Tbio
Family: Enzyme
Novelty: 0.23529412
Score: 0.674
Data Source: STRINGDB
GPATCH1
Tdark
Novelty: 3.6
Score: 0.623
Data Source: STRINGDB
ZADH2
Tbio
Family: Enzyme
Novelty: 0.05733397
Score: 0.613
Data Source: STRINGDB
FAM49B
Tbio
Novelty: 0.03801708
Score: 0.611
Data Source: STRINGDB
ACAD11
Tbio
Family: Enzyme
Novelty: 0.55263158
Score: 0.61
Data Source: STRINGDB
RADX
Tdark
Novelty: 0.00761985
Score: 0.605
Data Source: STRINGDB
DEUP1
Tdark
Novelty: 0.19856591
Score: 0.583
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.07

PubMed score by year
PubTator Score  3.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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