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Tdark
TMEM135
Transmembrane protein 135

Protein Summary
Description
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305494
  • ENSP00000306344
  • ENSG00000166575
  • ENST00000340353
  • ENSP00000345513

Symbol
  • PMP52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.9
histone modification site profile
0.8
microRNA
0.75
tissue
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
17
25
99.9
bone density
3
5
5
92.3
bone fracture
1
1
1
78
velocity of sound measurement
1
1
1
77.5
bone quantitative ultrasound measurement
3
2
4
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
25
99.9
bone density
5
92.3
bone fracture
1
78
velocity of sound measurement
1
77.5
bone quantitative ultrasound measurement
4
72.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 135
704963
Mouse
MGI:1920009
72759
Rat
RGD:1309948
293098
Dog
transmembrane protein 135
VGNC:47473
607444
Horse
transmembrane protein 135
VGNC:24197
100060782
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 135
Mouse
Rat
Dog
transmembrane protein 135
Horse
transmembrane protein 135
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86UB9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (31)
1 – 10 of 31
SMPD3
Tchem
Family:  Enzyme
Novelty:  0.01053328
p_int:  0.990423176
p_ni:  2.3e-8
p_wrong:  0.009576801
Score:  0.622
Data Source:  BioPlex,STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.927218515
p_ni:  0.072781485
Data Source:  BioPlex
ZCCHC10
Tdark
Novelty:  0.48625249
Score:  0.695
Data Source:  STRINGDB
CTDSPL2
Tbio
Family:  Enzyme
Novelty:  0.23254058
Score:  0.674
Data Source:  STRINGDB
GPATCH1
Tdark
Novelty:  0.93318176
Score:  0.623
Data Source:  STRINGDB
ZADH2
Tbio
Family:  Enzyme
Novelty:  0.11800677
Score:  0.613
Data Source:  STRINGDB
FAM49B
Tbio
Novelty:  0.02928708
Score:  0.611
Data Source:  STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
Score:  0.61
Data Source:  STRINGDB
RADX
Tdark
Novelty:  0.0935142
Score:  0.605
Data Source:  STRINGDB
DEUP1
Tbio
Novelty:  0.13274391
Score:  0.583
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.39

PubMed score by year
PubTator Score  3.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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