Tdark TMEM135 Transmembrane protein 135

Protein Summary

Description

Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.

Uniprot Accession IDs

• Q86UB9
• Q6AW91
• Q8ND01
• Q9H6M3

Gene Name

• TMEM135

Ensembl ID

• ENST00000305494
• ENSP00000306344
• ENSG00000166575
• ENST00000340353
• ENSP00000345513

Symbol

• PMP52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
transcription factor binding site profile	0.9
histone modification site profile	0.8
microRNA	0.75
tissue	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.57   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.57   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0