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Tbio
RPAIN
RPA-interacting protein

Protein Summary
Description
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327154
  • ENSP00000315069
  • ENSG00000129197
  • ENST00000381208
  • ENSP00000370605
  • ENST00000381209
  • ENSP00000370606
  • ENST00000405578
  • ENSP00000385814
  • ENST00000536255
  • ENSP00000439939
  • ENST00000539417
  • ENSP00000446453
  • ENST00000571558
  • ENSP00000458699
  • ENST00000573577
  • ENSP00000460162
  • ENST00000574003
  • ENSP00000467178
  • ENST00000575112
  • ENSP00000460354
  • ENST00000575599
  • ENSP00000458218

Symbol
  • RIP
  • RIP
  • HRIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor perturbation
0.74
transcription factor binding site profile
0.72
cellular component
0.67
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.05   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.05   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
RPA1
Tchem
Novelty:  0.00212665
p_int:  0.990373827
p_ni:  0.009626173
Score:  0.88
Data Source:  BioPlex,STRINGDB
UBR7
Tbio
Family:  Epigenetic
Novelty:  0.23270052
p_int:  0.95989729
p_ni:  0.04010271
Score:  0.534
Data Source:  BioPlex,STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.759
Data Source:  STRINGDB
TIPRL
Tbio
Novelty:  0.01885339
Score:  0.65
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.58
Data Source:  STRINGDB
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
Score:  0.576
Data Source:  STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
Score:  0.568
Data Source:  STRINGDB
RAD51B
Tbio
Novelty:  0.00302521
Score:  0.531
Data Source:  STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
Score:  0.53
Data Source:  STRINGDB
NUPL2
Tbio
Novelty:  0.05516243
Score:  0.525
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
2
2
86.1
body mass index
8
3
9
85.2
myeloid white cell count
1
1
1
78.1
leukocyte count
1
1
1
73.9
neutrophil count
2
1
2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
86.1
body mass index
9
85.2
myeloid white cell count
1
78.1
leukocyte count
1
73.9
neutrophil count
2
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RPA interacting protein
VGNC:9571
748614
Macaque
RPA interacting protein
711897
Mouse
MGI:1916973
69723
Rat
RGD:1308492
287463
Dog
RPA interacting protein
VGNC:45705
607256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RPA interacting protein
Macaque
RPA interacting protein
Mouse
Rat
Dog
RPA interacting protein
Publication Statistics
PubMed Score 21.05
PubMed score by year
PubTator Score 17.20
PubTator score by year
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Related Publications
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PMID
Year
Title