Tchem PBRM1 Protein polybromo-1

Protein Summary

Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q86U86
• A1L381
• A1L382
• A4FUJ7
• Q1RMD1
• Q1RMD2
• Q96MS2
• Q9H2T3
• Q9H2T4
• Q9H2T5
• Q9H301
• Q9H314
• hPB1

Gene Name

• PBRM1

Ensembl ID

• ENST00000296302
• ENSP00000296302
• ENSG00000163939
• ENST00000337303
• ENSP00000338302
• ENST00000356770
• ENSP00000349213
• ENST00000394830
• ENSP00000378307
• ENST00000409057
• ENSP00000386593
• ENST00000409114
• ENSP00000386643
• ENST00000409767
• ENSP00000386601
• ENST00000410007
• ENSP00000386529
• ENST00000412587
• ENSP00000404579

Symbol

• BAF180
• PB1
• PB1
• BAF180

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.88
virus perturbation	0.88
kinase perturbation	0.81
microRNA	0.76
transcription factor	0.76

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Reader / Bromodomain / Protein Polybromo-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.55   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.55   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0