Protein Summary
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
- ENST00000296302
- ENSP00000296302
- ENSG00000163939
- ENST00000337303
- ENSP00000338302
- ENST00000356770
- ENSP00000349213
- ENST00000394830
- ENSP00000378307
- ENST00000409057
- ENSP00000386593
- ENST00000409114
- ENSP00000386643
- ENST00000409767
- ENSP00000386601
- ENST00000410007
- ENSP00000386529
- ENST00000412587
- ENSP00000404579
- BAF180
- PB1
- PB1
- BAF180
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.88 | ||
virus perturbation | 0.88 | ||
kinase perturbation | 0.81 | ||
microRNA | 0.76 | ||
transcription factor | 0.76 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.1 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 152 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.1 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 152 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 9
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (9)
1 – 9 of 9
Protein Data Bank (22)
1 – 5 of 22
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (10)
Reactome (8)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RMTs methylate histone arginines | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RMTs methylate histone arginines | ||||
Gene Ontology Terms (11)
Functions (2)
Components (3)
Processes (6)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (150)
1 – 10 of 150
BCL7C
Novelty: 0.55480559
p_int: 0.999998684
p_ni: 0.000001316
Score: 0.832
Data Source: BioPlex,STRINGDB
SMARCC2
Family: TF; Epigenetic
Novelty: 0.04842565
p_int: 0.999998385
p_ni: 0.000001615
Score: 0.999
Data Source: BioPlex,STRINGDB
SMARCB1
Novelty: 0.00155975
p_int: 0.999998322
p_ni: 0.000001678
Score: 0.995
Data Source: BioPlex,STRINGDB
BCL7A
Novelty: 0.09319798
p_int: 0.999980854
p_ni: 0.000019146
Score: 0.808
Data Source: BioPlex,STRINGDB
DPF3
Family: Epigenetic
Novelty: 0.09141321
p_int: 0.999965334
p_ni: 0.000034666
Score: 0.987
Data Source: BioPlex,STRINGDB
SMARCE1
Family: TF
Novelty: 0.02547452
p_int: 0.999926179
p_ni: 0.000073821
Score: 0.995
Data Source: BioPlex,STRINGDB
NUP50
Novelty: 0.05793903
p_int: 0.999910299
p_ni: 0.000089701
Score: 0.632
Data Source: BioPlex,STRINGDB
SMARCD1
Novelty: 0.04468954
p_int: 0.999866448
p_ni: 0.000133551
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
RPL37
Novelty: 0.03416838
p_int: 0.992390059
p_ni: 0.007609941
Data Source: BioPlex
RPL11
Novelty: 0.00566877
p_int: 0.944417554
p_ni: 0.055582446
Data Source: BioPlex
Publication Statistics
PubMed Score 105.10
PubMed score by year
PubTator Score 483.58
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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