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Tchem
PBRM1
Protein polybromo-1

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296302
  • ENSP00000296302
  • ENSG00000163939
  • ENST00000337303
  • ENSP00000338302
  • ENST00000356770
  • ENSP00000349213
  • ENST00000394830
  • ENSP00000378307
  • ENST00000409057
  • ENSP00000386593
  • ENST00000409114
  • ENSP00000386643
  • ENST00000409767
  • ENSP00000386601
  • ENST00000410007
  • ENSP00000386529
  • ENST00000412587
  • ENSP00000404579

Symbol
  • BAF180
  • PB1
  • PB1
  • BAF180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
virus perturbation
0.88
kinase perturbation
0.81
microRNA
0.76
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.55   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.55   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0