Tchem PBRM1 Protein polybromo-1

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Reader / Bromodomain / Protein Polybromo-1

Protein Summary

Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q86U86
• A1L381
• A1L382
• A4FUJ7
• Q1RMD1
• Q1RMD2
• Q96MS2
• Q9H2T3
• Q9H2T4
• Q9H2T5
• Q9H301
• Q9H314
• hPB1

Gene Name

• PBRM1

Ensembl ID

• ENST00000296302
• ENSP00000296302
• ENSG00000163939
• ENST00000337303
• ENSP00000338302
• ENST00000356770
• ENSP00000349213
• ENST00000394830
• ENSP00000378307
• ENST00000409057
• ENSP00000386593
• ENST00000409114
• ENSP00000386643
• ENST00000409767
• ENSP00000386601
• ENST00000410007
• ENSP00000386529
• ENST00000412587
• ENSP00000404579

Symbol

• BAF180
• PB1
• PB1
• BAF180

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.88
virus perturbation	0.88
kinase perturbation	0.81
microRNA	0.76
transcription factor	0.76

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.1   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.1   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (9)

Explore Active Ligands

1 – 9 of 9

CHEMBL2177300

PBRM1Tchem TF; Epigenetic

IC50: 6.2

CHEMBL3752911

PBRM1Tchem TF; Epigenetic

Kd: 7.32000017

CHEMBL3822689

PBRM1Tchem TF; Epigenetic

Kd: 6.91

CHEMBL3819245

PBRM1Tchem TF; Epigenetic

Kd: 7.55

CHEMBL3823055

PBRM1Tchem TF; Epigenetic

Kd: 6.77

CHEMBL3823132

PBRM1Tchem TF; Epigenetic

Kd: 6.86

CHEMBL3823524

PBRM1Tchem TF; Epigenetic

Kd: 6.9

CHEMBL3899245

PBRM1Tchem TF; Epigenetic

Kd: 7.37

CHEMBL3824067

PBRM1Tchem TF; Epigenetic

Kd: 6.85

Protein Data Bank (22)

1 – 5 of 22

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (10)

Reactome (8)

KEGG (1)

WikiPathways (1)

Chromatin modifying enzymes (R-HSA-3247509)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RMTs methylate histone arginines	49 targets	R-HSA-3214858

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RMTs methylate histone arginines	49 targets	R-HSA-3214858

Gene Ontology Terms (11)

Functions (2)

Components (3)

Processes (6)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (150)

Explore Interacting Targets

1 – 10 of 150

• See Interactions on String-DB

BCL7C

Tdark

Novelty: 0.55480559

p_int: 0.999998684

p_ni: 0.000001316

Score: 0.832

Data Source: BioPlex,STRINGDB

SMARCC2

Tbio

Family: TF; Epigenetic

Novelty: 0.04842565

p_int: 0.999998385

p_ni: 0.000001615

Score: 0.999

Data Source: BioPlex,STRINGDB

SMARCB1

Tbio

Novelty: 0.00155975

p_int: 0.999998322

p_ni: 0.000001678

Score: 0.995

Data Source: BioPlex,STRINGDB

BCL7A

Tbio

Novelty: 0.09319798

p_int: 0.999980854

p_ni: 0.000019146

Score: 0.808

Data Source: BioPlex,STRINGDB

DPF3

Tbio

Family: Epigenetic

Novelty: 0.09141321

p_int: 0.999965334

p_ni: 0.000034666

Score: 0.987

Data Source: BioPlex,STRINGDB

SMARCE1

Tbio

Family: TF

Novelty: 0.02547452

p_int: 0.999926179

p_ni: 0.000073821

Score: 0.995

Data Source: BioPlex,STRINGDB

NUP50

Tbio

Novelty: 0.05793903

p_int: 0.999910299

p_ni: 0.000089701

Score: 0.632

Data Source: BioPlex,STRINGDB

SMARCD1

Tbio

Novelty: 0.04468954

p_int: 0.999866448

p_ni: 0.000133551

p_wrong: 1e-9

Score: 0.996

Data Source: BioPlex,STRINGDB

RPL37

Tbio

Novelty: 0.03416838

p_int: 0.992390059

p_ni: 0.007609941

Data Source: BioPlex

RPL11

Tbio

Novelty: 0.00566877

p_int: 0.944417554

p_ni: 0.055582446

Data Source: BioPlex

Publication Statistics

PubMed Score  105.10

PubMed score by year

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PubTator Score  483.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCE

1-70

LFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKL

70-140

WDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQK

140-210

LPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIF

210-280

YMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQ

280-350

YGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDY

350-420

YQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARR

420-490

DDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYK

490-560

IILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD

560-630

DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTI

630-700

KKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSH

700-770

VPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF

770-840

QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKL

840-910

PKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCI

910-980

ERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPEN

980-1050

FRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSR

1050-1120

AEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAY

1120-1190

FYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR

1190-1260

YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMG

1260-1330

EEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQ

1330-1400

HPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPP

1400-1470

TPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMN

1470-1540

QGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAY

1540-1610

LKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNI

1610-1680

RQAYNLENV

1680-1689

MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV

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Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
Bromodomain
Chromatin regulator
Complete proteome
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein