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Tbio
PABPN1
Polyadenylate-binding protein 2

Protein Summary
Description
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216727
  • ENSP00000216727
  • ENSG00000100836
  • ENST00000397276
  • ENSP00000380446

Symbol
  • PAB2
  • PABP2
  • OPMD
  • PAB2
  • PABII
  • PABP2
  • PABP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
virus perturbation
1
co-expressed gene
0.96
kinase perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
66.9
reticulocyte measurement
2
2
2
33
monocyte count
1
1
1
10.7
diet measurement
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
66.9
reticulocyte measurement
2
33
monocyte count
1
10.7
diet measurement
1
7.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BCL2L2-PABPN1 readthrough [Source:HGNC Symbol;Acc:HGNC:42959]
Rat
RGD:619928
116697
Dog
poly(A) binding protein nuclear 1
VGNC:50550
100170671
Cow
poly(A) binding protein nuclear 1
VGNC:53575
282298
Pig
polyadenylate-binding protein 2 [Source:RefSeq peptide;Acc:NP_001230477]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BCL2L2-PABPN1 readthrough [Source:HGNC Symbol;Acc:HGNC:42959]
Rat
Dog
poly(A) binding protein nuclear 1
Cow
poly(A) binding protein nuclear 1
Pig
polyadenylate-binding protein 2 [Source:RefSeq peptide;Acc:NP_001230477]
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86U42-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Host Interactions with Influenza Factors
Reactome
Infectious disease
Reactome
Influenza Infection
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Host Interactions with Influenza Factors
Infectious disease
Influenza Infection
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (324)
1 – 10 of 324
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.984861655
p_ni: 0.015138345
Score: 0.188
Data Source: BioPlex,STRINGDB
CCDC9
Tdark
Novelty: 0.73149492
p_int: 0.95573865
p_ni: 0.04426135
Data Source: BioPlex
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.987
Data Source: STRINGDB
ALYREF
Tbio
Novelty: 0.00523802
Score: 0.982
Data Source: STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
Score: 0.981
Data Source: STRINGDB
NCBP1
Tbio
Novelty: 0.01228885
Score: 0.981
Data Source: STRINGDB
CPSF1
Tbio
Novelty: 0.04396897
Score: 0.979
Data Source: STRINGDB
DDX39B
Tbio
Family: Enzyme
Novelty: 0.012548
Score: 0.977
Data Source: STRINGDB
CSTF1
Tbio
Novelty: 0.08711712
Score: 0.977
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  307.00

PubMed score by year
PubTator Score  170.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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