Tbio ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial

Protein Summary

Description

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q86U28
• A6NFF1
• A8K3W3
• G3V291
• Q8IYZ0
• Q96BB2

Gene Name

• ISCA2

Ensembl ID

• ENST00000554924
• ENSP00000450523
• ENSG00000165898
• ENST00000556816
• ENSP00000452007

Symbol

• HBLD1
• ISA2
• HBLD1
• MMDS4
• c14_5557

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.84
histone modification site profile	0.78
kinase perturbation	0.66
cell type or tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.93   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.93   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0