Tbio SETD3 Histone-lysine N-methyltransferase setd3

Protein Summary

Description

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). Acts as a transcriptional activator. Plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.

Uniprot Accession IDs

• Q86TU7
• A0PJU3
• A5PLP0
• B4DZE8
• Q0VAQ2
• Q659C0
• Q86TU8
• Q96GY9
• Q9H5U5

Gene Name

• SETD3

Ensembl ID

• ENST00000329331
• ENSP00000327910
• ENSG00000183576
• ENST00000331768
• ENSP00000327436

Symbol

• C14orf154
• hSETD3
• C14orf154

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
disease perturbation	0.95
molecular function	0.81
histone modification site profile	0.8
biological process	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.33   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.33   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0