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Tdark
MRPL52
39S ribosomal protein L52, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355151
  • ENSP00000347277
  • ENSG00000172590
  • ENST00000397496
  • ENSP00000380633
  • ENST00000397505
  • ENSP00000380642
  • ENST00000553711
  • ENSP00000451303
  • ENST00000555345
  • ENSP00000451081
  • ENST00000556840
  • ENSP00000451481
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor binding site profile
0.86
small molecule perturbation
0.85
virus perturbation
0.83
cellular component
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
1
1
0
1.1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L52
VGNC:12564
742831
Macaque
mitochondrial ribosomal protein L52
712367
Mouse
MGI:1916086
68836
Rat
RGD:1309297
361037
Dog
mitochondrial ribosomal protein L52
VGNC:43405
480240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L52
Macaque
mitochondrial ribosomal protein L52
Mouse
Rat
Dog
mitochondrial ribosomal protein L52
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86TS9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (129)
1 – 10 of 129
MRPL55
Tdark
Novelty: 0.55956177
p_int: 0.999369282
p_ni: 0.000630718
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.998945744
p_ni: 0.001054257
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL45
Tdark
Novelty: 0.42464896
p_int: 0.998273002
p_ni: 0.001726998
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.997998122
p_ni: 0.001999485
p_wrong: 0.000002393
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL2
Tdark
Novelty: 1.01237797
p_int: 0.997851781
p_ni: 0.002148219
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.995710304
p_ni: 0.004289696
Score: 0.997
Data Source: BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty: 0.03765684
p_int: 0.995375691
p_ni: 0.004624309
Score: 0.982
Data Source: BioPlex,STRINGDB
MRPL16
Tdark
Novelty: 0.38562971
p_int: 0.995069603
p_ni: 0.004930397
Score: 0.988
Data Source: BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
p_int: 0.993048362
p_ni: 0.00691672
p_wrong: 0.000034919
Score: 0.259
Data Source: BioPlex,STRINGDB
MRPL27
Tbio
Novelty: 0.15636105
p_int: 0.991740872
p_ni: 0.008259128
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.08

PubMed score by year
PubTator Score  0.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer