Tdark MRPL52 39S ribosomal protein L52, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86TS9
• A6NMQ8
• A8MXK5
• A8MYI6
• G3XCN9
• Q6NVH8
• L52mt

Gene Name

• MRPL52

Ensembl ID

• ENST00000355151
• ENSP00000347277
• ENSG00000172590
• ENST00000397496
• ENSP00000380633
• ENST00000397505
• ENSP00000380642
• ENST00000553711
• ENSP00000451303
• ENST00000555345
• ENSP00000451081
• ENST00000556840
• ENSP00000451481

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor binding site profile	0.86
small molecule perturbation	0.85
virus perturbation	0.83
cellular component	0.67

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	1	1	0	1.1	2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	0	1.1	2

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L52	VGNC:12564	742831
Macaque	mitochondrial ribosomal protein L52		712367
Mouse	mitochondrial ribosomal protein L52	MGI:1916086	68836
Rat	mitochondrial ribosomal protein L52	RGD:1309297	361037
Dog	mitochondrial ribosomal protein L52	VGNC:43405	480240

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L52
Macaque	mitochondrial ribosomal protein L52
Mouse	mitochondrial ribosomal protein L52
Rat	mitochondrial ribosomal protein L52
Dog	mitochondrial ribosomal protein L52

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86TS9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (6)

Reactome (6)

Metabolism of proteins (R-HSA-392499)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Gene Ontology Terms (7)

Functions (1)

Components (3)

Processes (3)

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GO Term	Evidence	Assigned by
structural constituent of ribosome	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Protein-Protein Interactions (129)

Explore Interacting Targets

1 – 10 of 129

• See Interactions on String-DB

MRPL55

Tdark

Novelty: 0.55956177

p_int: 0.999369282

p_ni: 0.000630718

Score: 0.994

Data Source: BioPlex,STRINGDB

MRPS30

Tbio

Novelty: 0.08115544

p_int: 0.998945744

p_ni: 0.001054257

Score: 0.995

Data Source: BioPlex,STRINGDB

MRPL45

Tdark

Novelty: 0.42464896

p_int: 0.998273002

p_ni: 0.001726998

Score: 0.987

Data Source: BioPlex,STRINGDB

MRPL4

Tdark

Novelty: 0.27290276

p_int: 0.997998122

p_ni: 0.001999485

p_wrong: 0.000002393

Score: 0.995

Data Source: BioPlex,STRINGDB

MRPL2

Tdark

Novelty: 1.01237797

p_int: 0.997851781

p_ni: 0.002148219

Score: 0.99

Data Source: BioPlex,STRINGDB

MRPL13

Tbio

Novelty: 0.04173503

p_int: 0.995710304

p_ni: 0.004289696

Score: 0.997

Data Source: BioPlex,STRINGDB

GADD45GIP1

Tbio

Novelty: 0.03765684

p_int: 0.995375691

p_ni: 0.004624309

Score: 0.982

Data Source: BioPlex,STRINGDB

MRPL16

Tdark

Novelty: 0.38562971

p_int: 0.995069603

p_ni: 0.004930397

Score: 0.988

Data Source: BioPlex,STRINGDB

HNRNPA1

Tchem

Novelty: 0.0020871

p_int: 0.993048362

p_ni: 0.00691672

p_wrong: 0.000034919

Score: 0.259

Data Source: BioPlex,STRINGDB

MRPL27

Tbio

Novelty: 0.15636105

p_int: 0.991740872

p_ni: 0.008259128

p_wrong: 1e-9

Score: 0.986

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  1.08

PubMed score by year

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PubTator Score  0.07

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Complete proteome
Mitochondrion
Polymorphism
Reference proteome
Ribonucleoprotein
Ribosomal protein
Transit peptide

GWAS Trait Find Similar Targets

prostate carcinoma