MRPL52
39S ribosomal protein L52, mitochondrial
Protein Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
- ENST00000355151
- ENSP00000347277
- ENSG00000172590
- ENST00000397496
- ENSP00000380633
- ENST00000397505
- ENSP00000380642
- ENST00000553711
- ENSP00000451303
- ENST00000555345
- ENSP00000451081
- ENST00000556840
- ENSP00000451481
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor binding site profile | 0.86 | ||
small molecule perturbation | 0.85 | ||
virus perturbation | 0.83 | ||
cellular component | 0.67 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.35 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 57 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.35 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 57 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
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Protein-Protein Interactions (129)
1 – 10 of 129
MRPL55
Novelty: 0.55956177
p_int: 0.999369282
p_ni: 0.000630718
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPS30
Novelty: 0.08115544
p_int: 0.998945744
p_ni: 0.001054257
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL45
Novelty: 0.42464896
p_int: 0.998273002
p_ni: 0.001726998
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL4
Novelty: 0.27290276
p_int: 0.997998122
p_ni: 0.001999485
p_wrong: 0.000002393
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL2
Novelty: 1.01237797
p_int: 0.997851781
p_ni: 0.002148219
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL13
Novelty: 0.04173503
p_int: 0.995710304
p_ni: 0.004289696
Score: 0.997
Data Source: BioPlex,STRINGDB
GADD45GIP1
Novelty: 0.03765684
p_int: 0.995375691
p_ni: 0.004624309
Score: 0.982
Data Source: BioPlex,STRINGDB
MRPL16
Novelty: 0.38562971
p_int: 0.995069603
p_ni: 0.004930397
Score: 0.988
Data Source: BioPlex,STRINGDB
HNRNPA1
Novelty: 0.0020871
p_int: 0.993048362
p_ni: 0.00691672
p_wrong: 0.000034919
Score: 0.259
Data Source: BioPlex,STRINGDB
MRPL27
Novelty: 0.15636105
p_int: 0.991740872
p_ni: 0.008259128
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial translation | ||||
Reactome | Mitochondrial translation elongation | ||||
Reactome | Mitochondrial translation initiation | ||||
Reactome | Mitochondrial translation termination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Mitochondrial translation | ||||
Mitochondrial translation elongation | ||||
Mitochondrial translation initiation | ||||
Mitochondrial translation termination | ||||
Gene Ontology Terms (7)
Functions (1)
Components (3)
Processes (3)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 4 | 3 | 5.7 | 91 | ||||
mathematical ability | 3 | 2 | 3 | 84.7 | |||||
heel bone mineral density | 3 | 1 | 3 | 81.2 | |||||
cup-to-disc ratio measurement | 2 | 2 | 2 | 78.7 | |||||
Dupuytren Contracture | 1 | 1 | 0 | 1.3 | 71.6 | ||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 5.7 | 91 | ||||
mathematical ability | 3 | 84.7 | |||||
heel bone mineral density | 3 | 81.2 | |||||
cup-to-disc ratio measurement | 2 | 78.7 | |||||
Dupuytren Contracture | 0 | 1.3 | 71.6 | ||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L52 | VGNC:12564 | 742831 | |||||
Macaque | mitochondrial ribosomal protein L52 | 712367 | ||||||
Mouse | MGI:1916086 | 68836 | ||||||
Rat | RGD:1309297 | 361037 | ||||||
Dog | mitochondrial ribosomal protein L52 | VGNC:43405 | 480240 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L52 | |||||
Macaque | mitochondrial ribosomal protein L52 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitochondrial ribosomal protein L52 | |||||
Publication Statistics
PubMed Score 2.35
PubMed score by year
PubTator Score 0.07
PubTator score by year