You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TRPT1
tRNA 2'-phosphotransferase 1

Protein Classes
Protein Summary
Description
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317459
  • ENSP00000314073
  • ENSG00000149743
  • ENST00000394546
  • ENSP00000378050
  • ENST00000394547
  • ENSP00000378051
  • ENST00000541278
  • ENSP00000438683
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
cell type or tissue
0.73
virus perturbation
0.72
tissue sample
0.65
transcription factor
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
5
6
97
BMI-adjusted waist-hip ratio
6
5
9
97
urate measurement
1
5
5
94.4
triglyceride measurement
4
3
4
93.5
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
6
97
BMI-adjusted waist-hip ratio
9
97
urate measurement
5
94.4
triglyceride measurement
4
93.5
high density lipoprotein cholesterol measurement
5
92.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA phosphotransferase 1
VGNC:948
451288
Macaque
tRNA phosphotransferase 1
717911
Mouse
MGI:1333115
107328
Rat
RGD:1310831
293704
Dog
tRNA phosphotransferase 1
VGNC:47881
483765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA phosphotransferase 1
Macaque
tRNA phosphotransferase 1
Mouse
Rat
Dog
tRNA phosphotransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86TN4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (17)
1 – 10 of 17
DYNC1LI1
Tbio
Novelty:  0.02164556
p_int:  0.999873296
p_ni:  0.000126704
Score:  0.269
Data Source:  BioPlex,STRINGDB
STRIP1
Tbio
Novelty:  0.13320106
p_int:  0.981411703
p_ni:  0.018588297
Score:  0.259
Data Source:  BioPlex,STRINGDB
ZYG11B
Tbio
Novelty:  0.14657862
p_int:  0.882802222
p_ni:  0.117197778
Score:  0.189
Data Source:  BioPlex,STRINGDB
THYN1
Tbio
Novelty:  0.11624704
Score:  0.74
Data Source:  STRINGDB
TSEN34
Tdark
Family:  Enzyme
Novelty:  0.06726323
Score:  0.642
Data Source:  STRINGDB
NUDT22
Tbio
Novelty:  0.44528464
Score:  0.598
Data Source:  STRINGDB
ERI3
Tbio
Family:  Enzyme
Novelty:  0.08842487
Score:  0.589
Data Source:  STRINGDB
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
Score:  0.586
Data Source:  STRINGDB
VKORC1
Tclin
Family:  Enzyme
Novelty:  0.00135838
Score:  0.582
Data Source:  STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.518
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.62

PubMed score by year
PubTator Score  0.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: