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Tbio
SYVN1
E3 ubiquitin-protein ligase synoviolin

Protein Summary
Description
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294256
  • ENSP00000294256
  • ENSG00000162298
  • ENST00000307289
  • ENSP00000302035
  • ENST00000377190
  • ENSP00000366395
  • ENST00000526060
  • ENSP00000436984

Symbol
  • HRD1
  • KIAA1810
  • DER3
  • HRD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.91
transcription factor binding site profile
0.86
biological process
0.85
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.42   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.42   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (19)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
ER Quality Control Compartment (ERQC)
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Disease
Diseases of signal transduction
ER Quality Control Compartment (ERQC)
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (177)
1 – 10 of 177
FAM8A1
Tbio
Novelty: 0.08206001
p_int: 0.995790967
p_ni: 0.004209033
Score: 0.96
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.994512416
p_ni: 0.005487584
Data Source: BioPlex
SLC22A15
Tdark
Family: Transporter
Novelty: 0.22792289
p_int: 0.955539326
p_ni: 0.044460674
Data Source: BioPlex
NAAA
Tchem
Family: Enzyme
Novelty: 0.00368876
p_int: 0.925388158
p_ni: 0.074611842
Data Source: BioPlex
PIP
Tbio
Novelty: 0.00208509
p_int: 0.912325921
p_ni: 0.087674079
Data Source: BioPlex
EGFL6
Tbio
Novelty: 0.04347552
p_int: 0.840301289
p_ni: 0.159698711
Score: 0.798
Data Source: BioPlex,STRINGDB
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
p_int: 0.812503034
p_ni: 0.187496966
Data Source: BioPlex
WBP1
Tbio
Novelty: 1.24967974
p_int: 0.792582645
p_ni: 0.207417355
Score: 0.541
Data Source: BioPlex,STRINGDB
SLC24A5
Tbio
Family: Transporter
Novelty: 0.01224635
p_int: 0.766127345
p_ni: 0.233872654
Score: 0.296
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  55.42

PubMed score by year
PubTator Score  97.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer