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Tbio
TADA2B
Transcriptional adapter 2-beta

Protein Summary
Description
Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310074
  • ENSP00000308022
  • ENSG00000173011
  • ENST00000512388
  • ENSP00000423947
  • ENST00000515646
  • ENSP00000423181

Symbol
  • ADA2B
  • ADA2B
  • ADA2(beta)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
microRNA
0.81
protein domain
0.73
tissue sample
0.63
histone modification site profile
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.37   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.37   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
2
3
93
mosaic loss of chromosome Y measurement
2
1
2
64.7
platelet crit
2
1
2
60.6
monocyte percentage of leukocytes
1
1
1
49.5
platelet count
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
93
mosaic loss of chromosome Y measurement
2
64.7
platelet crit
2
60.6
monocyte percentage of leukocytes
1
49.5
platelet count
1
37.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcriptional adaptor 2B
VGNC:735
471134
Mouse
MGI:3035274
231151
Rat
RGD:1561605
289717
Dog
transcriptional adaptor 2B
VGNC:47071
488783
Horse
transcriptional adaptor 2B
VGNC:23846
100070335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcriptional adaptor 2B
Mouse
Rat
Dog
transcriptional adaptor 2B
Horse
transcriptional adaptor 2B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86TJ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
Metabolism of proteins
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (112)
1 – 10 of 112
TADA3
Tbio
Novelty: 0.01743814
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
TADA1
Tdark
Novelty: 0.09903801
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
SGF29
Tbio
Family: Epigenetic
Novelty: 0.0426456
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
TAF5L
Tbio
Family: Enzyme
Novelty: 0.29525944
p_int: 0.999999973
p_ni: 2.7e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
TERF2
Tbio
Family: TF
Novelty: 0.01003649
p_int: 0.999999902
p_ni: 9.8e-8
p_wrong: 1e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
TAF6L
Tdark
Family: Enzyme
Novelty: 0.7411477
p_int: 0.999999293
p_ni: 7.07e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
SUPT7L
Tdark
Novelty: 0.20661559
p_int: 0.999999043
p_ni: 9.56e-7
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
SUPT20H
Tbio
Novelty: 0.00625899
p_int: 0.999998966
p_ni: 9.55e-7
p_wrong: 8e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
SUPT3H
Tbio
Novelty: 0.13202683
p_int: 0.99999557
p_ni: 0.000003915
p_wrong: 5.15e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF9B
Tbio
Novelty: 0.0285313
p_int: 0.999982063
p_ni: 0.000017888
p_wrong: 4.9e-8
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.37

PubMed score by year
PubTator Score  1.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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