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Tchem
DPP9
Dipeptidyl peptidase 9

Protein Summary
Description
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262960
  • ENSP00000262960
  • ENSG00000142002
  • ENST00000594671
  • ENSP00000472224
  • ENST00000598800
  • ENSP00000469603

Symbol
  • DPRP2
  • DP9
  • DPLP9
  • DPRP2
  • DPP IX
  • DPRP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
histone modification site profile
0.83
tissue sample
0.64
cell type or tissue
0.61
tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.79   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.79   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 207
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (207)
1 – 10 of 207
talabostat
Rendered image for talabostat
CHEMBL210805
Rendered image for CHEMBL210805
Boronic acid derivative
Rendered image for Boronic acid derivative
CHEMBL237336,CHEMBL189881
Rendered image for CHEMBL237336,CHEMBL189881
CHEMBL195189
Rendered image for CHEMBL195189
CHEMBL209940
Rendered image for CHEMBL209940
CHEMBL380090
Rendered image for CHEMBL380090
CHEMBL436744
Rendered image for CHEMBL436744
CHEMBL481669
Rendered image for CHEMBL481669
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
1
1
0
1.2
56.4
1
1
0
1.3
54.4
1
1
0
1.3
53.7
body height
1
1
1
46.5
Oral ulcer
1
1
0
1
40.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
0
1.2
56.4
0
1.3
54.4
0
1.3
53.7
body height
1
46.5
Oral ulcer
0
1
40.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 9
VGNC:6621
100608569
Mouse
MGI:2443967
224897
Rat
RGD:1588575
301130
Dog
dipeptidyl peptidase 9
VGNC:40078
485033
Horse
dipeptidyl peptidase 9
VGNC:17298
100062517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 9
Mouse
Rat
Dog
dipeptidyl peptidase 9
Horse
dipeptidyl peptidase 9
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86TI2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Lung fibrosis
WikiPathways
Lung fibrosis
WikiPathways
Lung fibrosis
WikiPathways
Lung fibrosis
WikiPathways
Regulation of Actin Cytoskeleton
Name
Explore in Pharos
Explore in Source
Lung fibrosis
Lung fibrosis
Lung fibrosis
Lung fibrosis
Regulation of Actin Cytoskeleton
Protein-Protein Interactions (57)
1 – 10 of 57
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.999999633
p_ni:  3.67e-7
Data Source:  BioPlex
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.999811913
p_ni:  0.000188072
p_wrong:  1.5e-8
Data Source:  BioPlex
SPRED2
Tbio
Novelty:  0.04447225
p_int:  0.999772589
p_ni:  0.000227408
p_wrong:  3e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
p_int:  0.999583596
p_ni:  0.000416403
p_wrong:  1e-9
Data Source:  BioPlex
ENSA
Tbio
Novelty:  0.01642444
p_int:  0.999326835
p_ni:  0.000673163
p_wrong:  2e-9
Data Source:  BioPlex
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.998276446
p_ni:  0.001723554
Data Source:  BioPlex
DMTN
Tbio
Novelty:  0.01330153
p_int:  0.998144676
p_ni:  0.001855324
Score:  0.163
Data Source:  BioPlex,STRINGDB
PLPPR2
Tdark
Family:  Enzyme
Novelty:  1.03318406
p_int:  0.997569996
p_ni:  0.002430003
Data Source:  BioPlex
ANKRD10
Tdark
Novelty:  0.6861542
p_int:  0.99530963
p_ni:  0.004690359
p_wrong:  1.2e-8
Score:  0.22
Data Source:  BioPlex,STRINGDB
NEFL
Tbio
Novelty:  0.00049255
p_int:  0.993578888
p_ni:  0.006421112
Data Source:  BioPlex
Publication Statistics
PubMed Score  94.79

PubMed score by year
PubTator Score  61.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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