Tchem DPP9 Dipeptidyl peptidase 9

Protein Summary

Description

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86TI2
• O75273
• O75868
• Q1ZZB8
• Q6AI37
• Q6UAL0
• Q6ZMT2
• Q6ZNJ5
• Q8N2J7
• Q8N3F5
• Q8WXD8
• Q96NT8
• Q9BVR3
• DP9

Gene Name

• DPP9

Ensembl ID

• ENST00000262960
• ENSP00000262960
• ENSG00000142002
• ENST00000594671
• ENSP00000472224
• ENST00000598800
• ENSP00000469603

Symbol

• DPRP2
• DP9
• DPLP9
• DPRP2
• DPP IX
• DPRP-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.87
histone modification site profile	0.83
tissue sample	0.64
cell type or tissue	0.61
tissue	0.57

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Dipeptidyl Peptidase 9

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Dipeptidyl Peptidase 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.51   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 343   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.51   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 207

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4