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Tbio
TBC1D1
TBC1 domain family member 1

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261439
  • ENSP00000261439
  • ENSG00000065882
  • ENST00000508802
  • ENSP00000423651

Symbol
  • KIAA1108
  • TBC
  • TBC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.9
drug perturbation
0.87
trait
0.86
histone modification site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.82   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.82   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
2
2
88.2
lymphocyte count
2
1
2
83.2
neutrophil percentage of leukocytes
2
2
2
78.7
monocyte percentage of leukocytes
1
1
1
40.7
leukocyte count
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
88.2
lymphocyte count
2
83.2
neutrophil percentage of leukocytes
2
78.7
monocyte percentage of leukocytes
1
40.7
leukocyte count
1
28.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 1
VGNC:2963
461163
Macaque
TBC1 domain family member 1
697357
Mouse
MGI:1889508
57915
Rat
RGD:1304562
360937
Dog
TBC1 domain family member 1
VGNC:47129
479115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 1
Macaque
TBC1 domain family member 1
Mouse
Rat
Dog
TBC1 domain family member 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86TI0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Vesicle-mediated transport
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (65)
1 – 10 of 65
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999998777
p_ni:  5e-9
p_wrong:  0.000001218
Score:  0.251
Data Source:  BioPlex,STRINGDB
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.999524994
p_ni:  0.000230721
p_wrong:  0.000244285
Data Source:  BioPlex
RAB14
Tbio
Family:  Enzyme
Novelty:  0.01876172
Score:  0.946
Data Source:  STRINGDB
RAB10
Tbio
Family:  Enzyme
Novelty:  0.00870713
Score:  0.945
Data Source:  STRINGDB
RAB13
Tbio
Family:  Enzyme
Novelty:  0.02465609
Score:  0.943
Data Source:  STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.943
Data Source:  STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
Score:  0.931
Data Source:  STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
Score:  0.928
Data Source:  STRINGDB
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
Score:  0.921
Data Source:  STRINGDB
PRKAG2
Tchem
Family:  Enzyme
Novelty:  0.00741608
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  88.82

PubMed score by year
PubTator Score  56.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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