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Tbio
PEG10
Retrotransposon-derived protein PEG10

Protein Summary
Description
Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000482108
  • ENSP00000417587
  • ENSG00000242265

Symbol
  • EDR
  • KIAA1051
  • MAR2
  • MART2
  • MEF3L1
  • RGAG3
  • EDR
  • HB-1
  • Mar2
  • RTL2
  • MEF3L
  • Mart2
  • RGAG3
  • SIRH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.95
histone modification site profile
0.86
transcription factor binding site profile
0.85
interacting protein
0.81


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.76   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.76   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paternally expressed 10
VGNC:4463
472446
Mouse
MGI:2157785
170676
Dog
paternally expressed 10
VGNC:49685
482307
Cow
paternally expressed 10
VGNC:50004
618138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paternally expressed 10
Mouse
Dog
paternally expressed 10
Cow
paternally expressed 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86TG7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (84)
1 – 10 of 84
RTL8A
Tdark
Novelty: 1.2458167
p_int: 1
Score: 0.557
Data Source: BioPlex,STRINGDB
RTL8B
Tdark
Novelty: 2.29599566
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.59
Data Source: BioPlex,STRINGDB
LDOC1
Tbio
Novelty: 0.04366903
p_int: 0.999999991
p_wrong: 9e-9
Score: 0.625
Data Source: BioPlex,STRINGDB
RTL8C
Tbio
Novelty: 0.20316911
p_int: 0.999999601
p_ni: 3.99e-7
Score: 0.318
Data Source: BioPlex,STRINGDB
USP9X
Tbio
Family: Enzyme
Novelty: 0.00820155
p_int: 0.998637883
p_ni: 0.001362117
Score: 0.513
Data Source: BioPlex,STRINGDB
IQCB1
Tbio
Novelty: 0.02979098
p_int: 0.988000097
p_ni: 0.011999903
Score: 0.527
Data Source: BioPlex,STRINGDB
CEP290
Tbio
Novelty: 0.00526375
p_int: 0.980118237
p_ni: 0.011076475
p_wrong: 0.008805288
Score: 0.806
Data Source: BioPlex,STRINGDB
TCAF1
Tbio
Family: Enzyme
Novelty: 0.50366212
p_int: 0.904776616
p_ni: 0.095223384
Score: 0.243
Data Source: BioPlex,STRINGDB
SGCE
Tbio
Novelty: 0.00449577
Score: 0.836
Data Source: STRINGDB
SNRPN
Tbio
Novelty: 0.002157
Score: 0.737
Data Source: STRINGDB
Publication Statistics
PubMed Score  206.76

PubMed score by year
PubTator Score  228.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer