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Tbio
TMEM150A
Transmembrane protein 150A

Protein Summary
Description
Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306353
  • ENSP00000302715
  • ENSG00000168890
  • ENST00000334462
  • ENSP00000334708
  • ENST00000409668
  • ENSP00000387292

Symbol
  • TMEM150
  • TTN1
  • TM6P1
  • TMEM150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
transcription factor perturbation
0.61
tissue sample
0.59
virus perturbation
0.59
cell type or tissue
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
6
4
1.1
94.9
6
4
1
1.1
90
serum gamma-glutamyl transferase measurement
2
3
3
81.1
3
2
0
1.1
69.6
eosinophil count
3
1
3
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
94.9
1
1.1
90
serum gamma-glutamyl transferase measurement
3
81.1
0
1.1
69.6
eosinophil count
3
62.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 150A
VGNC:410
459367
Mouse
MGI:2385244
232086
Rat
RGD:619998
245966
Dog
transmembrane protein 150A
VGNC:47481
483080
Horse
transmembrane protein 150A
VGNC:24206
100053096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 150A
Mouse
Rat
Dog
transmembrane protein 150A
Horse
transmembrane protein 150A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86TG1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (36)
1 – 10 of 36
ACOX3
Tchem
Family:  Enzyme
Novelty:  0.04077258
p_int:  0.999998266
p_ni:  0.00000144
p_wrong:  2.94e-7
Score:  0.252
Data Source:  BioPlex,STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
p_int:  0.98491329
p_ni:  0.015086694
p_wrong:  1.6e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
YY1
Tbio
Family:  TF
Novelty:  0.00120891
p_int:  0.973999973
p_ni:  0.025998607
p_wrong:  0.00000142
Score:  0.295
Data Source:  BioPlex,STRINGDB
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.971060754
p_ni:  0.028934341
p_wrong:  0.000004904
Score:  0.295
Data Source:  BioPlex,STRINGDB
GOSR1
Tbio
Novelty:  0.03139481
p_int:  0.908785829
p_ni:  0.091212529
p_wrong:  0.000001642
Score:  0.189
Data Source:  BioPlex,STRINGDB
HELLS
Tbio
Family:  Enzyme
Novelty:  0.01348077
p_int:  0.855613703
p_ni:  0.144386293
p_wrong:  4e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
C2orf68
Tdark
Novelty:  0.7947239
Score:  0.83
Data Source:  STRINGDB
USP39
Tbio
Novelty:  0.03914006
Score:  0.786
Data Source:  STRINGDB
PSD4
Tbio
Novelty:  0.0674237
Score:  0.723
Data Source:  STRINGDB
RNF144B
Tbio
Family:  Enzyme
Novelty:  0.02487971
Score:  0.685
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.75

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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