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Tbio
PATL1
Protein PAT1 homolog 1

Protein Summary
Description
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300146
  • ENSP00000300146
  • ENSG00000166889

Symbol
  • Pat1b
  • hPat1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.96
virus perturbation
0.92
histone modification site profile
0.89
transcription factor binding site profile
0.78
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
31.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAT1 homolog 1, processing body mRNA decay factor
VGNC:10369
466618
Macaque
PAT1 homolog 1, processing body mRNA decay factor
699207
Mouse
MGI:2147679
225929
Rat
RGD:1305514
361736
Dog
PAT1 homolog 1, processing body mRNA decay factor
VGNC:44272
609696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAT1 homolog 1, processing body mRNA decay factor
Macaque
PAT1 homolog 1, processing body mRNA decay factor
Mouse
Rat
Dog
PAT1 homolog 1, processing body mRNA decay factor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86TB9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 5' to 3' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 5' to 3' exoribonuclease
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (96)
1 – 10 of 96
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999999998
p_ni:  2e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.99999999
p_ni:  1e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
IGHM
Tbio
p_int:  0.999999898
p_ni:  1.02e-7
Data Source:  BioPlex
LSM7
Tbio
Novelty:  0.09112723
p_int:  0.999999756
p_ni:  2.44e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.999992474
p_ni:  0.000007525
Score:  0.158
Data Source:  BioPlex,STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
p_int:  0.999807741
p_ni:  0.000192259
Score:  0.212
Data Source:  BioPlex,STRINGDB
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.994686812
p_ni:  0.005313186
p_wrong:  2e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.916307527
p_ni:  0.083692473
Score:  0.165
Data Source:  BioPlex,STRINGDB
LSM1
Tbio
Novelty:  0.00962392
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.83

PubMed score by year
PubTator Score  6.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer