Tbio PATL1 Protein PAT1 homolog 1

Protein Summary

Description

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).

Uniprot Accession IDs

• Q86TB9
• B3KXT9
• Q2TA86
• Q6P166
• Q8N9M6
• Q8NI63

Gene Name

• PATL1

Ensembl ID

• ENST00000300146
• ENSP00000300146
• ENSG00000166889

Symbol

• Pat1b
• hPat1b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.96
virus perturbation	0.92
histone modification site profile	0.89
transcription factor binding site profile	0.78
transcription factor	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Protein Pat1 Homolog 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Protein Pat1 Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.11   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.11   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0