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Tbio
RNF180
E3 ubiquitin-protein ligase RNF180

Protein Summary
Description
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296615
  • ENSP00000296615
  • ENSG00000164197
  • ENST00000389100
  • ENSP00000373752

Symbol
  • RINES
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.87
histone modification site profile
0.73
biological process
0.6
transcription factor
0.59
molecular function
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Protein-Protein Interactions (44)
1 – 10 of 44
RNF121
Tbio
Novelty: 0.24805367
Score: 0.599
Data Source: STRINGDB
RNF170
Tbio
Family: Enzyme
Novelty: 0.1117879
Score: 0.598
Data Source: STRINGDB
EIF4EBP1
Tbio
Novelty: 0.00098313
Score: 0.585
Data Source: STRINGDB
CGRRF1
Tdark
Novelty: 0.49690187
Score: 0.576
Data Source: STRINGDB
RNFT1
Tdark
Novelty: 1.15288082
Score: 0.575
Data Source: STRINGDB
BICDL1
Tdark
Novelty: 0.25314105
Score: 0.56
Data Source: STRINGDB
SREK1IP1
Tdark
Novelty: 1.39429464
Score: 0.56
Data Source: STRINGDB
XKRX
Tdark
Novelty: 0.35938148
Score: 0.558
Data Source: STRINGDB
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
Score: 0.55
Data Source: STRINGDB
SHISAL2B
Tdark
Novelty: 7.97175866
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.31

PubMed score by year
PubTator Score  8.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer