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Tbio
ZBTB33
Transcriptional regulator Kaiso

Protein Summary
Description
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326624
  • ENSP00000314153
  • ENSG00000177485
  • ENST00000557385
  • ENSP00000450969

Symbol
  • KAISO
  • ZNF348
  • ZNF348
  • ZNF-kaiso
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
virus perturbation
0.85
microRNA
0.8
transcription factor perturbation
0.8
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.26   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.26   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (82)
1 – 10 of 82
TRIML2
Tdark
Family:  Enzyme
Novelty:  0.38455379
p_int:  0.999996624
p_ni:  0.000003376
Score:  0.422
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999979412
p_ni:  0.000020588
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.99994452
p_ni:  0.00005548
Data Source:  BioPlex
CTNND1
Tbio
Novelty:  0.00335459
p_int:  0.998635266
p_ni:  0.001364734
Score:  0.997
Data Source:  BioPlex,STRINGDB
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.99825121
p_ni:  0.00174879
Data Source:  BioPlex
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.994022892
p_ni:  0.005977108
Data Source:  BioPlex
ENPP6
Tbio
Family:  Enzyme
Novelty:  0.06933544
p_int:  0.991678016
p_ni:  0.008321984
Data Source:  BioPlex
ZNF576
Tdark
Family:  TF
Novelty:  13.18548387
p_int:  0.984064519
p_ni:  0.015935481
Score:  0.163
Data Source:  BioPlex,STRINGDB
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
p_int:  0.97330947
p_ni:  0.02669053
Score:  0.19
Data Source:  BioPlex,STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.962856145
p_ni:  0.037143855
Score:  0.25
Data Source:  BioPlex,STRINGDB
Pathways (14)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Posttranslational regulation of adherens junction stability and dissassembly
Name
Explore in Pharos
Explore in Source
Posttranslational regulation of adherens junction stability and dissassembly
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 33
695801
Mouse
MGI:1927290
56805
Rat
RGD:6496755
100910807
Dog
zinc finger and BTB domain containing 33
VGNC:48531
100685062
Horse
zinc finger and BTB domain containing 33
VGNC:25144
100062002
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 33
Mouse
Rat
Dog
zinc finger and BTB domain containing 33
Horse
zinc finger and BTB domain containing 33
Publication Statistics
PubMed Score 92.26
PubMed score by year
PubTator Score 4.63
PubTator score by year