Tbio PIP4P1 Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Protein Summary

Description

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q86T03
• B2RA35
• Q86U09
• Q8WUC0
• Q9BU67
• Q9NSU8
• Type 1 PtdIns-4,5-P2 4-Ptase

Gene Name

• PIP4P1

Ensembl ID

• ENST00000250489
• ENSP00000250489
• ENSG00000165782
• ENST00000398020
• ENSP00000381102

Symbol

• C14orf9
• TMEM55B
• C14orf9
• TMEM55B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (3)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (59)

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1 – 10 of 59

• See Interactions on String-DB

TBC1D9B

Tdark

Novelty:  0.66719861

p_int:  0.995753932

p_ni:  0.004246068

Score:  0.328

Data Source:  BioPlex,STRINGDB

GLMN

Tbio

Novelty:  0.01940401

p_int:  0.935063883

p_ni:  0.064936117

Score:  0.228

Data Source:  BioPlex,STRINGDB

PIP5KL1

Tbio

Family:  Enzyme

Novelty:  0.15208771

Score:  0.914

Data Source:  STRINGDB

PIP4K2C

Tchem

Family:  Kinase

Novelty:  0.11466436

Score:  0.91

Data Source:  STRINGDB

PIP5K1C

Tchem

Family:  Kinase

Novelty:  0.0323077

Score:  0.909

Data Source:  STRINGDB

PIP4K2B

Tchem

Family:  Kinase

Novelty:  0.06261627

Score:  0.908

Data Source:  STRINGDB

PIP5K1B

Tbio

Family:  Kinase

Novelty:  0.05013433

Score:  0.906

Data Source:  STRINGDB

PIP5K1A

Tbio

Family:  Kinase

Novelty:  0.05039085

Score:  0.906

Data Source:  STRINGDB

PIP4K2A

Tbio

Family:  Kinase

Novelty:  0.01130885

Score:  0.905

Data Source:  STRINGDB

PIKFYVE

Tchem

Family:  Kinase

Novelty:  0.00441336

Score:  0.902

Data Source:  STRINGDB

Nearest Tclin Targets (2)

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Upstream (2)

1 – 2 of 2

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Phosphatidylinositol signaling system

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Phosphatidylinositol signaling system

Pathways (4)

KEGG (1)

PathwayCommons (3)

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Phosphatidylinositol signaling system	99 targets	path:hsa04070

Name	Explore in Pharos	Explore in Source
Phosphatidylinositol signaling system	99 targets	path:hsa04070

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (4)

Processes (2)

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GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	Inferred from Direct Assay (IDA)	FlyBase

Disease Associations (null)

No disease associations found

GWAS Traits (7)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mitochondrial DNA measurement	EFO_0006312	1	1	1		73.6
metabolite measurement	EFO_0004725	1	1	1		65.6
aspartate aminotransferase measurement	EFO_0004736	2	1	1	6.8	62.1
Takayasu arteritis	EFO_1001857	1	1	0	1.6	27.3
serum alanine aminotransferase measurement	EFO_0004735	1	1	0	5.6	21.5

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mitochondrial DNA measurement	EFO_0006312	1		73.6
metabolite measurement	EFO_0004725	1		65.6
aspartate aminotransferase measurement	EFO_0004736	1	6.8	62.1
Takayasu arteritis	EFO_1001857	0	1.6	27.3
serum alanine aminotransferase measurement	EFO_0004735	0	5.6	21.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Endosome
Hydrolase
Lysosome
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
age at menopause
aspartate aminotransferase measurement
high density lipoprotein cholesterol measurement
metabolite measurement
mitochondrial DNA measurement
serum alanine aminotransferase measurement
Takayasu arteritis

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1	VGNC:3301	465201
Mouse	transmembrane protein 55b	MGI:2448501	219024
Rat	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1	RGD:1307475	364298
Dog	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1	VGNC:44573	482559
Horse	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1	VGNC:21465	100058648

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Mouse	transmembrane protein 55b
Rat	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Dog	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Horse	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

Publication Statistics

PubMed Score 7.00

PubMed score by year

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PubTator Score 2.86

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (6)

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PMID	Year	Title