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Tdark
TRAPPC6B
Trafficking protein particle complex subunit 6B

Protein Summary
Description
Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed:16025134, PubMed:16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330149
  • ENSP00000330289
  • ENSG00000182400
  • ENST00000347691
  • ENSP00000335171

Symbol
  • TPC6
  • NEDMEBA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
transcription factor binding site profile
0.72
kinase perturbation
0.66
tissue
0.62
microRNA
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (136)
1 – 10 of 136
TRAPPC1
Tbio
Novelty: 0.1875
p_int: 0.999999789
p_ni: 2.11e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
TRAPPC5
Tdark
Novelty: 1.63636364
p_int: 0.999999763
p_ni: 2.37e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty: 0.01745001
p_int: 0.999996934
p_ni: 0.000003066
Score: 0.997
Data Source: BioPlex,STRINGDB
BCL2L14
Tbio
Novelty: 0.04767234
p_int: 0.999962853
p_ni: 0.000037147
Score: 0.895
Data Source: BioPlex,STRINGDB
STMN4
Tbio
Novelty: 0.00798494
p_int: 0.999950478
p_ni: 0.000049522
Score: 0.81
Data Source: BioPlex,STRINGDB
GLB1
Tchem
Family: Enzyme
Novelty: 0.00274332
p_int: 0.999682239
p_ni: 0.000317751
p_wrong: 1e-8
Score: 0.735
Data Source: BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty: 0.05825243
p_int: 0.999159084
p_ni: 0.000840916
Score: 0.99
Data Source: BioPlex,STRINGDB
HOXB6
Tbio
Family: TF
Novelty: 0.02428861
p_int: 0.996463092
p_ni: 0.003536902
p_wrong: 6e-9
Data Source: BioPlex
CCDC102B
Tdark
Novelty: 0.44776119
p_int: 0.994009799
p_ni: 0.005990201
Data Source: BioPlex
KCTD3
Tdark
Novelty: 0.4635514
p_int: 0.987526784
p_ni: 0.012430583
p_wrong: 0.000042634
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.07

PubMed score by year
PubTator Score  3.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer