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Tbio
GLRX5
Glutaredoxin-related protein 5, mitochondrial

Protein Summary
Description
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity). This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331334
  • ENSP00000328570
  • ENSG00000182512

Symbol
  • C14orf87
  • GRX5
  • PRSA
  • SIDBA3
  • SPAHGC
  • FLB4739
  • PR01238
  • PRO1238
  • C14orf87
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
kinase perturbation
0.84
histone modification site profile
0.75
transcription factor binding site profile
0.72
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.53   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.53   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
BOLA3
Tbio
Novelty:  0.06292339
Score:  0.999
Data Source:  STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
Score:  0.993
Data Source:  Reactome,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
Score:  0.992
Data Source:  Reactome,STRINGDB
BOLA1
Tbio
Novelty:  0.1092583
Score:  0.991
Data Source:  STRINGDB
HSCB
Tbio
Novelty:  0.01330125
Score:  0.988
Data Source:  STRINGDB
GLRX2
Tbio
Novelty:  0.00928864
Score:  0.919
Data Source:  STRINGDB
CIAPIN1
Tbio
Novelty:  0.01359005
Score:  0.912
Data Source:  STRINGDB
ALAS2
Tbio
Family:  Enzyme
Novelty:  0.00491418
Score:  0.911
Data Source:  STRINGDB
SLC25A38
Tbio
Family:  Transporter
Novelty:  0.05237625
Score:  0.91
Data Source:  STRINGDB
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
Score:  0.889
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
81.4
mean corpuscular volume
1
1
1
65.3
red blood cell density measurement
1
1
1
53.3
mean reticulocyte volume
1
1
1
50.6
Waldenstrom macroglobulinemia
1
1
0
4.9
28.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
81.4
mean corpuscular volume
1
65.3
red blood cell density measurement
1
53.3
mean reticulocyte volume
1
50.6
Waldenstrom macroglobulinemia
0
4.9
28.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin 5
VGNC:3417
741187
Mouse
MGI:1920296
73046
Rat
RGD:1308383
362776
Dog
glutaredoxin 5
VGNC:50528
612417
Horse
glutaredoxin 5 [Source:HGNC Symbol;Acc:HGNC:20134]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin 5
Mouse
Rat
Dog
glutaredoxin 5
Horse
glutaredoxin 5 [Source:HGNC Symbol;Acc:HGNC:20134]
Publication Statistics
PubMed Score 90.53
PubMed score by year
PubTator Score 28.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title