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Tbio
GALNT10
Polypeptide N-acetylgalactosaminyltransferase 10

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates. This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297107
  • ENSP00000297107
  • ENSG00000164574
  • ENST00000377661
  • ENSP00000366889
  • ENST00000425427
  • ENSP00000415210

Symbol
  • GALNACT10
  • PPGALNACT10
  • PPGANTASE10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
PubMedID
0.82
transcription factor perturbation
0.8
histone modification site profile
0.73
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
1
1.1
85.2
1
2
0
1.1
34.8
self reported educational attainment
1
1
1
17.8
intelligence
1
1
1
17.8
feeling tense measurement
1
1
0
5.5
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
85.2
0
1.1
34.8
self reported educational attainment
1
17.8
intelligence
1
17.8
feeling tense measurement
0
5.5
14.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Protein-Protein Interactions (53)
1 – 10 of 53
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.999999595
p_ni: 1.1e-8
p_wrong: 3.95e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
ECSCR
Tbio
Novelty: 0.11603718
p_int: 0.999888839
p_ni: 0.000029529
p_wrong: 0.000081632
Data Source: BioPlex
MUC1
Tbio
Novelty: 0.00024203
Score: 0.959
Data Source: STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
Score: 0.958
Data Source: STRINGDB
MUC7
Tbio
Novelty: 0.00750654
Score: 0.945
Data Source: STRINGDB
MUC5AC
Tbio
Novelty: 0.00074159
Score: 0.941
Data Source: STRINGDB
MUC20
Tbio
Novelty: 0.04645313
Score: 0.93
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00304872
Score: 0.929
Data Source: STRINGDB
MUC12
Tbio
Novelty: 0.04323645
Score: 0.925
Data Source: STRINGDB
MUC5B
Tbio
Novelty: 0.000832
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.33

PubMed score by year
PubTator Score  11.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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