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Tchem
GALNT10
Polypeptide N-acetylgalactosaminyltransferase 10

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates. This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297107
  • ENSP00000297107
  • ENSG00000164574
  • ENST00000377661
  • ENSP00000366889
  • ENST00000425427
  • ENSP00000415210

Symbol
  • GALNACT10
  • PPGALNACT10
  • PPGANTASE10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
PubMedID
0.82
transcription factor perturbation
0.8
histone modification site profile
0.73
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.32   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.32   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (53)
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.999999595
p_ni:  1.1e-8
p_wrong:  3.95e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ECSCR
Tbio
Novelty:  0.11603718
p_int:  0.999888839
p_ni:  0.000029529
p_wrong:  0.000081632
Data Source:  BioPlex
MUC1
Tchem
Novelty:  0.00024203
Score:  0.959
Data Source:  STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.958
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.945
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.941
Data Source:  STRINGDB
MUC20
Tbio
Novelty:  0.04645313
Score:  0.93
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.929
Data Source:  STRINGDB
MUC12
Tbio
Novelty:  0.04323645
Score:  0.925
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
8
6
10
91.4
electrocardiography
2
3
9
84.9
comparative body size at age 10, self-reported
1
1
1
73.9
7
3
1
1.1
60.2
1
2
0
1.1
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
10
91.4
electrocardiography
9
84.9
comparative body size at age 10, self-reported
1
73.9
1
1.1
60.2
0
1.1
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 10
VGNC:50756
462207
Macaque
polypeptide N-acetylgalactosaminyltransferase 10
714287
Mouse
MGI:1890480
171212
Rat
RGD:69409
170501
Dog
polypeptide N-acetylgalactosaminyltransferase 10
VGNC:41085
489165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 10
Macaque
polypeptide N-acetylgalactosaminyltransferase 10
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 10
Publication Statistics
PubMed Score 16.32
PubMed score by year
PubTator Score 11.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title