You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Protein Classes
Protein Summary
Description
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding dif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236342
  • ENSP00000236342
  • ENSG00000117682
  • ENST00000360009
  • ENSP00000353104
  • ENST00000525682
  • ENSP00000434984
  • ENST00000526219
  • ENSP00000434219

Symbol
  • HDS
  • DS
  • CIT
  • CPT
  • HDS
  • RP59
  • hCIT
  • DEDSM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.88
histone modification site profile
0.85
transcription factor binding site profile
0.8
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 799.37   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 799.37   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective DHDDS causes retinitis pigmentosa 59
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective DHDDS causes retinitis pigmentosa 59
Disease
Diseases associated with glycosylation precursor biosynthesis
Protein-Protein Interactions (84)
1 – 10 of 84
NUS1
Tbio
Family: Enzyme
Novelty: 0.03558983
p_int: 0.999999999
p_ni: 1e-9
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
FOXP4
Tbio
Family: TF
Novelty: 0.04123592
p_int: 0.999899559
p_ni: 0.000100441
Score: 0.536
Data Source: BioPlex,STRINGDB
TGFA
Tbio
Novelty: 0.00259473
p_int: 0.86059992
p_ni: 0.000170703
p_wrong: 0.139229376
Data Source: BioPlex
FDPS
Tclin
Family: Enzyme
Novelty: 0.00202381
Score: 0.978
Data Source: STRINGDB
GGPS1
Tchem
Family: Enzyme
Novelty: 0.00446019
Score: 0.971
Data Source: STRINGDB
PDSS1
Tbio
Family: Enzyme
Novelty: 0.01260939
Score: 0.958
Data Source: STRINGDB
FNTA
Tbio
Family: Enzyme
Novelty: 0.04343929
Score: 0.946
Data Source: STRINGDB
PDSS2
Tbio
Family: Enzyme
Novelty: 0.01416723
Score: 0.939
Data Source: STRINGDB
FNTB
Tchem
Family: Enzyme
Novelty: 0.13625417
Score: 0.933
Data Source: STRINGDB
FDFT1
Tchem
Family: Enzyme
Novelty: 0.0023237
Score: 0.891
Data Source: STRINGDB
Publication Statistics
PubMed Score  799.37

PubMed score by year
PubTator Score  43.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: