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Tbio
SDCCAG8
Serologically defined colon cancer antigen 8

Protein Summary
Description
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis. This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366541
  • ENSP00000355499
  • ENSG00000054282
  • ENST00000622598
  • ENSP00000483550
  • ENSG00000276111

Symbol
  • CCCAP
  • NPHP10
  • BBS16
  • CCCAP
  • SLSN7
  • NPHP10
  • hCCCAP
  • HSPC085
  • NY-CO-8
  • CCCAP SLSN7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
transcription factor binding site profile
0.88
transcription factor
0.86
virus perturbation
0.79
phenotype
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
6
5
5.9
94.4
self reported educational attainment
5
6
5
5.9
94.4
mathematical ability
4
6
6
91.3
mathematical ability
4
6
6
91.3
glomerular filtration rate
5
3
5
6.7
89.9
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
5.9
94.4
self reported educational attainment
5
5.9
94.4
mathematical ability
6
91.3
mathematical ability
6
91.3
glomerular filtration rate
5
6.7
89.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serologically defined colon cancer antigen 8
469732
Macaque
serologically defined colon cancer antigen 8
705545
Mouse
MGI:1924066
76816
Rat
RGD:727781
305002
Dog
serologically defined colon cancer antigen 8
490374
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serologically defined colon cancer antigen 8
Macaque
serologically defined colon cancer antigen 8
Mouse
Rat
Dog
serologically defined colon cancer antigen 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86SQ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (177)
1 – 10 of 177
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.999999983
p_ni:  8e-9
p_wrong:  9e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999999919
p_ni:  7.9e-8
p_wrong:  1e-9
Data Source:  BioPlex
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.999997285
p_ni:  0.000002715
Score:  0.209
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999993629
p_ni:  0.000006279
p_wrong:  9.3e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
p_int:  0.999993578
p_ni:  0.000006412
p_wrong:  1e-8
Score:  0.686
Data Source:  BioPlex,STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.999988727
p_ni:  0.000011152
p_wrong:  1.21e-7
Score:  0.741
Data Source:  BioPlex,STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.981
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.981
Data Source:  STRINGDB
IQCB1
Tbio
Novelty:  0.02979098
Score:  0.98
Data Source:  STRINGDB
OFD1
Tbio
Novelty:  0.01032841
Score:  0.979
Data Source:  STRINGDB
Publication Statistics
PubMed Score  24.22

PubMed score by year
PubTator Score  10.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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