Tbio ADGRA1 Adhesion G protein-coupled receptor A1

Protein Summary

Description

Orphan receptor. This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q86SQ6
• A5HL16
• A6NG50
• Q5T234
• Q86SN7
• Q96JJ9

Gene Name

• ADGRA1

Ensembl ID

• ENST00000392606
• ENSP00000376383
• ENSG00000197177
• ENST00000392607
• ENSP00000376384
• ENST00000607359
• ENSP00000475778

Symbol

• GPR123
• KIAA1828
• GPR123

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.59
cell line	0.55
cell type or tissue	0.42
tissue	0.42
chemical	0.41

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor A1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.66   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.66   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0