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Tbio
ADGRG6
Adhesion G-protein coupled receptor G6

Protein Summary
Description
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230173
  • ENSP00000230173
  • ENSG00000112414
  • ENST00000296932
  • ENSP00000296932
  • ENST00000367608
  • ENSP00000356580
  • ENST00000367609
  • ENSP00000356581

Symbol
  • DREG
  • GPR126
  • VIGR
  • APG1
  • DREG
  • VIGR
  • LCCS9
  • PR126
  • GPR126
  • PS1TP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.92
transcription factor perturbation
0.91
histone modification site profile
0.78
transcription factor binding site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.49   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.49   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
NAALADL1
Tbio
Family:  Enzyme
Novelty:  0.02355714
Score:  0.726
Data Source:  STRINGDB
SELL
Tchem
Novelty:  0.00030025
Score:  0.724
Data Source:  STRINGDB
CCRL2
Tchem
Family:  GPCR
Novelty:  0.00294533
Score:  0.671
Data Source:  STRINGDB
SBF2
Tbio
Novelty:  0.02647873
Score:  0.649
Data Source:  STRINGDB
NPR3
Tchem
Novelty:  0.00227442
Score:  0.64
Data Source:  STRINGDB
LIN28B
Tbio
Family:  TF
Novelty:  0.00564546
Score:  0.64
Data Source:  STRINGDB
UCHL1
Tchem
Family:  Enzyme
Novelty:  0.00056075
Score:  0.634
Data Source:  STRINGDB
MCM6
Tbio
Novelty:  0.00675724
Score:  0.621
Data Source:  STRINGDB
GSTCD
Tbio
Family:  Enzyme
Novelty:  0.11613228
Score:  0.582
Data Source:  STRINGDB
FLNB
Tbio
Novelty:  0.00568768
Score:  0.573
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
15
18
98.2
body height
9
9
11
6.5
98.1
FEV/FEC ratio
2
4
4
97.8
3
5
0
1.2
96
peak expiratory flow
1
3
3
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
18
98.2
body height
11
6.5
98.1
FEV/FEC ratio
4
97.8
0
1.2
96
peak expiratory flow
3
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G6
VGNC:7885
463034
Mouse
MGI:1916151
215798
Rat
RGD:1308551
308376
Dog
adhesion G protein-coupled receptor G6
VGNC:37648
484013
Horse
adhesion G protein-coupled receptor G6
VGNC:15111
100060706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G6
Mouse
Rat
Dog
adhesion G protein-coupled receptor G6
Horse
adhesion G protein-coupled receptor G6
Publication Statistics
PubMed Score 82.49
PubMed score by year
PubTator Score 23.94
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title