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Tbio
ADGRG6
Adhesion G-protein coupled receptor G6

Protein Summary
Description
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230173
  • ENSP00000230173
  • ENSG00000112414
  • ENST00000296932
  • ENSP00000296932
  • ENST00000367608
  • ENSP00000356580
  • ENST00000367609
  • ENSP00000356581

Symbol
  • DREG
  • GPR126
  • VIGR
  • APG1
  • DREG
  • VIGR
  • LCCS9
  • PR126
  • GPR126
  • PS1TP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.92
transcription factor perturbation
0.91
histone modification site profile
0.78
transcription factor binding site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.12   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.12   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (56)
1 – 10 of 56
NAALADL1
Tbio
Family: Enzyme
Novelty: 0.03818008
Score: 0.726
Data Source: STRINGDB
SELL
Tchem
Novelty: 0.00035489
Score: 0.724
Data Source: STRINGDB
CCRL2
Tchem
Family: GPCR
Novelty: 0.00460699
Score: 0.671
Data Source: STRINGDB
SBF2
Tbio
Novelty: 0.03307411
Score: 0.649
Data Source: STRINGDB
NPR3
Tchem
Novelty: 0.00281298
Score: 0.64
Data Source: STRINGDB
LIN28B
Tbio
Family: TF
Novelty: 0.00685329
Score: 0.64
Data Source: STRINGDB
UCHL1
Tchem
Family: Enzyme
Novelty: 0.00069785
Score: 0.634
Data Source: STRINGDB
MCM6
Tbio
Novelty: 0.0090985
Score: 0.621
Data Source: STRINGDB
GSTCD
Tbio
Family: Enzyme
Novelty: 0.19076326
Score: 0.582
Data Source: STRINGDB
FLNB
Tbio
Novelty: 0.00295671
Score: 0.573
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.12

PubMed score by year
PubTator Score  23.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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