Tbio PHLDB2 Pleckstrin homology-like domain family B member 2

Protein Summary

Description

Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).

Uniprot Accession IDs

• Q86SQ0
• A5PKZ3
• Q59EA8
• Q68CY3
• Q6NT98
• Q8N8U8
• Q8NAB1
• Q8NCU5

Gene Name

• PHLDB2

Ensembl ID

• ENST00000393923
• ENSP00000377500
• ENSG00000144824
• ENST00000393925
• ENSP00000377502
• ENST00000412622
• ENSP00000405292
• ENST00000431670
• ENSP00000405405
• ENST00000481953
• ENSP00000418319

Symbol

• LL5B
• LL5b
• LL5beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.91
transcription factor perturbation	0.91
drug perturbation	0.87
kinase perturbation	0.84
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 33   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0